Evidence map›Paper›PMID 42373370›Full record

ReviewTrends in cell biology2026

Horizontal transfer of mitochondria in cancer: The physiology reborn in disease?

Gustavo Ayala, Simon Grelet

Abstract readReview
In one paragraph

Review in Trends in cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Gustavo AyalaDepartment of Pathology and Laboratory Medicine, McGovern School of Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Simon GreletDepartment of Biochemistry and Molecular Biology, Frederick P. Whiddon College of Medicine, University of South Alabama, Mobile, AL, USA; Department of Oncology Science, College of Medicine, University of Oklahoma Health Campus, Oklahoma City, OK, USA. Electronic address: simon-grelet@ou.edu.

Funding

Intercellular Transfer of Mitochondria at the Nerve-Cancer InterfaceR37CA292711 · NCI · UNIVERSITY OF SOUTH ALABAMA · PI Simon Grelet · 2025 to 2026
$733k
NCI NIH HHS R37 CA292711
6 · The paper itself

Abstract

Intercellular mitochondria transfer has emerged as a new form of cell-to-cell communication with profound consequences for cellular fate. A growing body of evidence defines mitochondria transfer between cells as a new pathological program in which cancer cells appropriate functional mitochondria from donor cells, thereby co-opting conserved physiological mechanisms of energy allocation to gain bioenergetic and phenotypic advantages. Our recent work demonstrates the prevalence of mitochondria transfer at the nerve-cancer interface, with neurons, though not exclusively, serving as a prominent source of the organelle. This suggests an unrecognized role of the nervous system in systemic energy redistribution and indicates that tumors may exploit this ancient, physiologically grounded mechanism to fuel progression and metastasis.

Indexed as

cancer neurometabolismkleptoplasmymitochondria transfer

Identifiers

PMID42373370
PMCPMC13334562

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.