Evidence map›Paper›PMID 42374128›Full record

ArticleMolecular psychiatry2026

Cannabis use and glutamate across the psychosis spectrum: in vivo evidence from 7T proton magnetic resonance spectroscopy.

David R Roalf, Tyler M Moore, Jacquelyn Stifelman, Maggie K Pecsok, Ally Atkins, Erica B Baller, Monica E Calkins, Mariella De Biasi, Christian G Kohler, Christina Mastracchio and 10 more

Abstract read
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In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

David R RoalfDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. roalf@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0002-1728-9782
Tyler M MooreDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-1384-0151
Jacquelyn StifelmanDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Maggie K PecsokDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Ally AtkinsDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Erica B BallerDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Monica E CalkinsDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Mariella De BiasiDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Christian G KohlerDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Christina MastracchioDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Arianna MordyDepartment of Psychology, University of California Los Angeles, Los Angeles, CA, USA.
Heather RobinsonDepartment of Psychological Sciences, University of Connecticut, Storrs, CT, USA.
Ravinder ReddyCenter for Advanced Metabolic Imaging in Precision Medicine (CAMIPM), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-4580-2392
Ravi Prakash Reddy NangaCenter for Advanced Metabolic Imaging in Precision Medicine (CAMIPM), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kosha RuparelDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Sage Rush-GoebelDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Daniel H WolfDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-9731-8781
Ruben C GurDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-4082-8502
Raquel E GurDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
J Cobb ScottDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Funding

Ultra-high field GluCEST MRI and MRS in youth at risk for psychosisR01MH120174 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI ROALF, DAVID R · 2020 to 2024
$3.8M
Leveraging Ultra-High Field MRI to Elucidate Glutamatergic Mechanisms of rTMS in DepressionF30MH136690 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Margaret Kasey Pecsok · 2024 to 2026
$129k
NIMH NIH HHS F30 MH136690NIMH NIH HHS R01 MH120174U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH117014U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH119185U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH119219U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH119738U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH120174U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH131566
6 · The paper itself

Abstract

Cannabis use is linked to elevated psychosis risk, yet the neurobiological mechanisms that couple use to symptom expression remain unclear. Because glutamatergic dysregulation has been implicated in both cannabis effects and psychosis vulnerability, we examined whether brain glutamate relates to dimensional psychosis symptoms as a function of cannabis use across the psychosis spectrum. Seventy-nine participants-typically developing controls, clinical high-risk individuals, and patients with psychosis-completed dimensional clinical assessments, detailed cannabis use surveys, urine toxicology, and ultra-high-field 7T magnetic resonance spectroscopy (

Identifiers

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.