Evidence map›Paper›PMID 42374129›Full record

ArticleMolecular psychiatry2026

Genome-wide genetic overlap between fear-based disorders and generalised anxiety disorder.

Abigail R Ter Kuile, Brittany L Mitchell, Sang Hyuck Lee, Geneviève Morneau-Vaillancourt, Megan Skelton, Jonathan R I Coleman, Helena L Davies, Jessica Mundy, Alicia J Peel, Christopher Hübel and 25 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Abigail R Ter KuileInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-7869-3754
Brittany L MitchellBrain and Mental Health program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0002-9050-1516
Sang Hyuck LeeInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-5610-033X
Geneviève Morneau-VaillancourtInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-5322-6252
Megan SkeltonInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-7619-349X
Jonathan R I ColemanInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-6759-0944
Helena L DaviesInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-9419-1009
Jessica MundyInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0001-5513-8902
Alicia J PeelInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-6144-5412
Christopher HübelInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-1267-8287
Molly R DaviesInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0003-3483-9907
Anna E FürtjesSchool of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-6590-4957
Zain AhmadInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-6940-8851
Yuhao LinInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Brett N AdeyInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0003-4356-4079
Thomas McGregorInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0003-0024-7049
Alish PalmosInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0001-5748-6652
Johan ZvrskovecInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-8862-0874
Matthew HotopfInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-3980-4466
Gursharan KalsiInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-5156-7176
Daniel J SmithCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-2267-1951
David VealeInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-1717-4766
James T R WaltersCentre for Neuropsychiatric Genetics and Genomics, National Centre for Mental Health, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0002-6980-4053
Chérie ArmourResearch Centre for Stress, Trauma, and Related Conditions, School of Psychology, Queen's University Belfast, Belfast, Northern Ireland, UK.ORCID http://orcid.org/0000-0001-7649-3874
Colette R HirschInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0003-3579-2418
Andrew M McIntoshInstitute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-0198-4588
Naomi R WrayInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0001-7421-3357
Sarah E MedlandBrain and Mental Health program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0003-1382-380X
Enda M ByrneChild Health Research Centre, The University of Queensland, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0002-9491-7797
Nicholas G MartinBrain and Mental Health program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0003-4069-8020
Nathalie KingstonNational Institute for Health and Care Research (NIHR) BioResource, Cambridge Biomedical Campus, Cambridge University Hospitals, Cambridge, UK.ORCID http://orcid.org/0000-0002-9190-2231
John R BradleyNational Institute for Health and Care Research (NIHR) BioResource, Cambridge Biomedical Campus, Cambridge University Hospitals, Cambridge, UK.ORCID http://orcid.org/0000-0002-7774-8805
NIHR BioResource
Gerome BreenInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0003-2053-1792
Thalia C EleyInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. thalia.eley@kcl.ac.uk.ORCID http://orcid.org/0000-0001-6458-0700

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Twin studies reveal high genetic overlap between anxiety disorders and depression, contributing to the internalising spectrum. Some genetic specificity for fear-based anxiety disorders (fear), distinct from general anxiety and depression (distress), has also emerged. Limited datasets with detailed phenotyping across anxiety disorders have restricted most genome-wide association studies (GWAS) to "any anxiety diagnosis". Additional genome-wide evidence to discern genetic differences between fear and distress is required. We conducted GWAS meta-analyses of fear (panic, agoraphobia, specific phobia, social anxiety disorder) and generalised anxiety disorder (GAD), measured using brief single-item and detailed symptom-based diagnoses from three datasets. We explored two control group criteria: phenotype-specific (fear/GAD) or broader anxiety/depression screening. We identified one independent genome-wide significant locus and three gene-level associations with fear (up to 35,523 N

Identifiers

PMID42374129

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.