ArticleBMC gastroenterology2026
Painful gastric glitch: an acute epigastric pain triggered by specific food as a new phenotype of postprandial epigastric pain syndrome.
Article in BMC gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND AND
aimPostprandial epigastric pain syndrome was recently suggested as a disorder of gut-brain interaction. We assessed gastroduodenal motility and histology in patients with acute epigastric pain triggered by specific foods.
methodsIn this case-control, exploratory study, patients with epigastric pain and matched controls underwent upper endoscopy to exclude organic disease and gastroduodenal biopsies for histology. All participants underwent a dynamic gastroduodenal MRI, with a baseline acquisition followed by a food-trigger intake and three MRI acquisitions at 15-minute intervals.
resultsWe studied seven pairs of participants (57% women, 33.3 ± 10.7 years old), all with unrevealing endoscopy. During the MRI, epigastric pain patients had pain crises that scored 6.6 ± 2.4 of a maximum of 10 points, triggered by caipirinha, red wine, banana, and coffee. No control subject had a pain crisis. Epigastric pain patients and controls did not differ in gastric motor parameters (P > 0.05), including accommodation, wall motion, and gastric emptying. Epigastric pain patients showed a negative correlation between pain score and wall motion time to peak (r = -0.81, P = 0.027). The duodenal mast cell count was higher in epigastric pain patients than in controls [median 140 (interquartile 25-75%: 117-153) vs. 86 (76-117); P = 0.020].
conclusionsIn patients presenting with acute epigastric pain following specific food intake, pain intensity might correlate with gastric wall motion parameters and duodenal mast cell infiltration. After confirmatory studies, such a postprandial epigastric pain syndrome might be recognized as a painful gastric glitch.
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