Evidence map›Paper›PMID 42374427›Full record

ArticleJournal of orthopaedic surgery and research2026

The Clock

Qijing Zhang, Yanhong Liu, Yuwen Chen, Yanqing Zhou, Zuoqin Yan, Ruizhe Qian, Chao Lu, Bingxuan Hua

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic surgery and research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qijing ZhangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Yanhong LiuDepartment of General Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Yuwen ChenDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Yanqing ZhouDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Zuoqin YanDepartment of orthopedics, Zhongshan hospital, Fudan University, Shanghai, 200032, China.
Ruizhe QianDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. rzqian@shmu.edu.cn.
Chao LuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. luchao@shmu.edu.cn.
Bingxuan HuaDepartment of orthopedics, Zhongshan hospital, Fudan University, Shanghai, 200032, China. hua.bingxuan@zs-hospital.sh.cn.

Funding

National Natural Science Foundation of China 32171164National Natural Science Foundation of China 32371220
6 · The paper itself

Abstract

backgroundOsteoarthritis (OA) is a chronic degenerative joint disease characterized by cartilage breakdown and disrupted joint homeostasis. Mitochondrial dysfunction in chondrocytes contributes to cartilage degeneration, but the mechanisms linking circadian dysregulation to mitochondrial homeostasis in OA remain incompletely understood. Clock

methodsTwo Gene Expression Omnibus datasets of human OA cartilage were integrated for bioinformatics analysis. OA severity was assessed in Clock

resultsIntegrated analysis of public datasets revealed circadian rhythm- related transcriptional alterations in human OA cartilage. Clock

conclusionCLOCK contributes to mitochondrial homeostasis in chondrocytes by regulating Sirt3 transcription and modulating the SIRT3-SOD2 K68 acetylation pathway. Disruption of this regulatory pathway may represent a mechanism linking circadian dysfunction to OA progression.

Indexed as

CLOCK ProteinsHomeostasisMitochondriaMutationOsteoarthritisSirtuin 3AnimalsCells, CulturedChondrocytesCircadian RhythmDisease Models, AnimalHumansMaleMiceClock protein, mouseCLOCK ProteinsSirt3 protein, mouseSirtuin 3CLOCKMitochondriaOsteoarthritisSIRT3

Identifiers

PMID42374427
PMCPMC13584504

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.