SynthesisItalian journal of pediatrics2026
Incidence, mortality, and survival trends of retinoblastoma in children: a systematic review and meta-analysis of population-based studies.
Synthesis in Italian journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRetinoblastoma (RB) is the most common childhood intraocular malignancy, with substantial global disparities in outcomes. This study aimed to provide pooled estimates of incidence, survival, mortality, and metastasis based on population-based data.
methodsA systematic review and meta-analysis was conducted in PubMed, Scopus, Web of Science, Embase, and the Cochrane Library through August 2025. Eligible studies were population- or registry-based and reported at least one epidemiological outcome. Random-effects models were applied, with assessments of heterogeneity, publication bias, and subgroup analyses.
resultsTwenty-five studies (52 study arms) were included. The global pooled incidence of RB was 0.12 per 1,000,000 (95% CI: 0.09-0.14), with high heterogeneity (I
conclusionsRB incidence and survival show striking geographic and socioeconomic disparities. Delayed diagnosis and limited access to care drive persistently poor outcomes in many low-resource regions, underscoring the need for improved registries, earlier detection, and equitable treatment worldwide.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.