Evidence map›Paper›PMID 42374604›Full record

ArticleGut microbes2026

Perinatal ampicillin exposure alters murine maternal fecal bile acid and acylcarnitine profiles.

Simone Zuffa, Sydney P Thomas, Abubaker Patan, Ipsita Mohanty, Yasin El Abiead, Victoria Deleray, Kine Eide Kvitne, Armin Kousha, Emi Suzuki, Chih Ming Tsai and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Simone ZuffaSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-7237-3402
Sydney P ThomasSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-8261-1195
Abubaker PatanSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-1415-7829
Ipsita MohantySkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Yasin El AbieadSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Victoria DeleraySkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Kine Eide KvitneSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-8118-7660
Armin KoushaDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.ORCID 0009-0003-0461-9951
Emi SuzukiDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Chih Ming TsaiDivision of Infectious Diseases, Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Griffith NguyenSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Benjamin HoSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
George Y LiuDivision of Infectious Diseases, Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Victor NizetSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Pieter C DorresteinSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-3003-1030
Fatemeh AskarianDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-7438-4671
Shirley M TsunodaSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-3974-8038

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maternal intrapartum antibiotic prophylaxis (IAP) and postpartum maternal antibiotic usage are increasingly common and have been linked to altered growth and immune development in offspring. However, the mechanisms underlying these effects, particularly those arising from indirect early-life exposure to antibiotics, remain poorly understood. Here, using a preclinical murine model, we examined the impact of

Indexed as

AmpicillinAnti-Bacterial AgentsBile Acids and SaltsCarnitineFecesGastrointestinal MicrobiomeAnimalsBacteriaFemaleMetabolomeMiceMice, Inbred C57BLPregnancyacylcarnitineAmpicillinAnti-Bacterial AgentsBile Acids and SaltsCarnitineAmpicillinantibioticsmicrobiomepregnancyuntargeted metabolomics

Identifiers

PMID42374604
PMCPMC13321893

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.