ReviewJournal of diabetes2026
Clonal Hematopoiesis and Type 2 Diabetes: A Narrative Review.
Review in Journal of diabetes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Clonal hematopoiesis (CH) refers to an expanded clonal hematopoietic cell population due to acquired mutations conferring a selective growth advantage. Once considered a premalignant hematological state, CH has now been causally associated with cardiovascular diseases (CVDs) and several aging-related clinical conditions. Emerging evidence suggests that CH is at the intersection of aging and metabolic disorders. CH carriers exhibit a higher risk of Type 2 diabetes, potentially through the obesity-inflammation-insulin resistance axis. Moreover, CH confers a higher risk of CVD and is associated with a poorer prognosis in patients with diabetes compared to noncarriers. In addition, CH has been associated with the development of microvascular complications, including retinopathy and kidney disease in patients with diabetes, although inconsistent findings exist. Preclinical studies found that antidiabetic medication metformin might slow down clonal expansion of CH, while clinical data suggest that anti-inflammatory medications confer better clinical outcomes for certain CH carriers, although their relevance for patients with diabetes remains to be elucidated. In this narrative review, we also briefly discuss the barriers to clinical adoption of CH detection and highlight the knowledge gaps that should be addressed in future work.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.