Evidence map›Paper›PMID 42375356›Full record

ReviewFrontiers in immunology2026

Circular RNAs as molecular bridges: dual regulation of ferroptosis and immunity in cancer.

Songbai Xu, Peiyi Liang, Tie Lin, Guangxin Zhang, Xiying Fu, Yicun Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Songbai XuDepartment of Neurosurgery, First Hospital of Jilin University, Changchun, China.
Peiyi LiangDepartment of Medical Research Center, Second Hospital of Jilin University, Changchun, China.
Tie LinDepartment of Cerebral Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Guangxin ZhangDepartment of Thoracic Surgery, Second Hospital of Jilin University, Changchun, China.
Xiying FuDepartment of Endocrinology, Second Hospital of Jilin University, Changchun, China.
Yicun WangDepartment of Medical Research Center, Second Hospital of Jilin University, Changchun, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs (circRNAs) are covalently closed single-stranded RNA molecules generated by back-splicing events of precursor mRNAs, characterized by superior structural stability, strict tissue specificity, and diverse regulatory functions. Ferroptosis is an iron-dependent, lipid peroxidation-driven regulated cell death (RCD) distinct from classical apoptosis and necrosis; remodeling of the tumor immune microenvironment (TIME) directly modulates cancer progression and therapeutic efficacy. Both are core targets in cancer biology and translational oncology. Emerging evidence shows circRNAs act as "molecular bridges" to simultaneously regulate ferroptosis and anti-tumor immunity via miRNA sponging, protein interaction/scaffolding, and

Indexed as

FerroptosisImmunityNeoplasmsRNA, CircularAnimalsBiomarkers, TumorGene Expression Regulation, NeoplasticHumansMicroRNAsRNA, Competitive EndogenousTumor MicroenvironmentBiomarkers, TumorMicroRNAsRNA, CircularRNA, Competitive Endogenouscancer therapycircular RNAferroptosisferroptosis-immunity crosstalkmolecular bridgetumor immune microenvironment

Identifiers

PMID42375356
PMCPMC13310680

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.