ArticleOpen veterinary journal2026
Histological effect of methotrexate on submandibular salivary glands in albino rats (
Article in Open veterinary journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Methotrexate (MTX), a potent chemotherapeutic agent, is known for its efficacy in the treatment of various malignancies. However, its use is often accompanied by adverse effects on non-target tissues, including the salivary glands. Aim: This study aimed to identify the histological events and effects of MTX on the salivary glands of the experimental animals (rats). Methods: This study used albino rats ( Results: Histological analysis revealed significant alterations in the submandibular gland tissue of the MTX-treated animals compared with the control group. These histological alterations underscore the potential cytotoxic effects of MTX on the salivary glands, which may contribute to the development of xerostomia (dry mouth) and other oral complications in patients undergoing MTX therapy. Conclusion: MTX administration in albino rats induces histological changes in the submandibular salivary glands. Therefore, further studies using special dyes are recommended to detect more specific changes, as well as the use of some medicinal herbs to reduce the harmful effects of the drug.
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