ArticleNeuroscience applied2026
Shared genetic architecture between psychiatric and insulin-related traits in the general population.
Article in Neuroscience applied, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Genetic overlap and shared risk loci between autism spectrum disorder and cardiometabolic traits.Molecular psychiatry · 2026Article
- Estimation of direct and indirect polygenic effects and gene-environment interactions using polygenic scores in case-parent trio studies.Nature genetics · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Psychiatric conditions, like Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), and Obsessive-Compulsive Disorder (OCD) are complex heritable disorders that frequently co-occur with insulin resistance (IR)-related conditions, such as obesity and type 2 diabetes mellitus. Traditional genetic case-control comparisons are challenged by the extent of heterogeneity and comorbidity within and across these conditions. In this study we used psychiatry-related traits in the general population in multivariate analyses to explore the potential genetic links with insulin-related traits. Using large-scale genetic studies (N = 17,666-697,734) genomic structural equation modeling was applied to identify the factor structure best representing the joint genetic architecture of traits in the population that are linked to ADHD, ASD, and OCD, and five IR-related measures: body mass index (BMI), fasting plasma glucose (FPG), fasting plasma insulin, glycated haemoglobin (HbA1c), and the Homeostatic Model assessment for IR (HOMA-IR). Next, multivariate genome-wide association analyses were performed on the psychiatry-IR related factors to explore genetic associations, followed by functional mapping and annotation of the genetic results. Factor analyses indicated that a three-factor model fitted the data best (χ2(df = 9) = 18.79, AIC = 56.8, CFI = 0.99, SRMR = 0.068). Two of the three genetic factors included both psychiatric and insulin-related traits, one factor connected ADHD symptoms with three IR-related measures (BMI, FPG, HbA1c) and another factor OCD symptoms with HbA1c. Genetic analyses revealed 57 genes significantly associated with the ADHD-IR factor (p < 2.961e-06) and one gene,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.