Clocks slide rather than freeze during torpor in the mouse.

Timna Hitrec, Ludovico Taddei, Lukasz Chrobok, Megan Elley, William S R Wheatley, Anthony E Pickering, Michael T Ambler

Abstract read

In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Timna HitrecSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.

Ludovico TaddeiSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.

Lukasz ChrobokSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.

Megan ElleySchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.

William S R WheatleySchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.

Anthony E PickeringSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.

Michael T AmblerSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Torpor is an energy-saving strategy used by animals in response to environmental challenges. Torpor is subject to circadian influence, but the effect of torpor itself on circadian rhythms is poorly understood. We investigated whether torpor alters circadian behavior by assessing locomotor activity after torpor in mice emerging into constant darkness (without Zeitgebers). Torpor was induced by food deprivation or by chemogenetic re-activation of "torpor-active" preoptic area neurons. In both conditions, torpor did not disrupt circadian rhythmicity, although a significant phase advance of ∼40 min was associated with arousal from fasting-induced torpor. Increased wheel-running activity occurred before torpor, likely reflecting food-seeking behavior. After emergence from fasting-induced torpor, locomotor activity decreased, while food/water intake increased to balance any nutritional deficit back to pre-torpor levels. Together, these findings suggest that torpor, and the associated hypothermia, does not disturb circadian function and that torpor (or arousal) acts as a non-photic phase advance stimulus.

Indexed as

Behavioral neuroscienceMolecular mechanism of behaviorSystems neuroscience

Identifiers

PMID42375523

DOI10.1016/j.isci.2026.116402

PMCPMC13310930

What Socratic holds

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LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.