ArticleiScience2026
Tandem single-cell epigenetic and transcriptomic analysis reveals spatiotemporally distinct genomic features among testis cell lineages.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The mammalian testis develops through coordinated differentiation of germline and somatic lineages. How chromatin maturation and epigenetic states guide testis development is not well understood. To address this, we generated paired single-nucleus chromatin and transcriptomic data from mouse testis cells from embryonic day 14.5 through postnatal day 4. Across lineages, epigenetic maturation differed temporally during development, spatially within the genome, and organizationally with bifurcating or linear trajectories. For instance, germ cell chromatin accessibility specifically at distal intergenic regions linked to genes implicated in spermatogonial stem cell function. Sertoli cells within seminiferous tubules or the rete displayed region-specific chromatin profiles. Among interstitial cells, epigenetic maturation marked canonical lineage drivers and modulated diverging cell fates. Finally, motif enrichment demonstrated cell-type specific activity among transcription factors, and cell-to-cell communication inferences illuminated interconnected networks among lineages. These findings highlight distinct maturations guiding testis development and identify candidate regulators with potential relevance to infertility.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.