A novel corneal epithelial cell culture assay for assessing topical antivirals against herpes simplex virus keratitis.

Hidenobu Kuniyoshi, Yui Numata, Mina Sasano, Hironori Hayashi, Nobuo Fuse, Stefan G Sarafianos, Eiichi N Kodama

Abstract read

In one paragraph

Article in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hidenobu KuniyoshiDepartment of Infectious Diseases, Graduate School of Medicine, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.

Yui NumataDepartment of Infectious Diseases, Graduate School of Medicine, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.

Mina SasanoDivision of Infectious Diseases, International Research Institute of Disaster Science, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.

Hironori HayashiDepartment of Infectious Diseases, Graduate School of Medicine, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.

Nobuo FuseTohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8573, Japan.

Stefan G SarafianosLaboratory of Biochemical Pharmacology, Department of Pediatrics, Center for ViroScience and Cure, Emory University School of Medicine, Children's Healthcare of Atlanta, 1760 Haygood Drive NE, Atlanta, GA, 30322, USA.

Eiichi N KodamaDepartment of Infectious Diseases, Graduate School of Medicine, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Various in vitro models have been used to study HSV infection, but corneal epithelial-based assay systems for evaluating antiviral activity remain limited. In this study, we established a in vitro assay of HSV keratitis using the CRL-11516, an immortalized human corneal epithelial (HCE) cell line. HSV readily infected HCE cells and exerted cytopathic effects. These effects were quantified

Indexed as

AntiviralCorneaHerpesHSVIn vitroKeratitisModel

Identifiers

PMID42375683

DOI10.1016/j.bbrep.2026.102676

PMCPMC13311990

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.