SynthesisFrontiers in cardiovascular medicine2026
Incidence and risk factors of acute kidney injury following Stanford type A aortic dissection surgery: a systematic review and meta-analysis.
Synthesis in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: This study aims to synthesize the existing evidence to identify the incidence of AKI following surgery for TAAD and its primary risk factors. Methods: Systematically searched PubMed, Embase, Web of Science, the Cochrane Library, CNKI, Wanfang, VIP, and the China Biomedical Literature Database to identify studies published from the inception of each database through January 6, 2026, regarding the incidence and risk factors of postoperative AKI following TAAD. Two researchers independently screened the literature and extracted data, and the Newcastle-Ottawa Scale (NOS) was used to assess study quality. Meta-analysis was performed using Stata 15.0 software. Results: A total of 44 studies were included, with a total sample size of 11,983 patients, of whom 6,115 developed AKI. The meta-analysis showed that the overall incidence of postoperative AKI following TAAD was 50.72%. Subgroup analysis showed that the incidence rate was higher when diagnosed using the KDIGO criteria compared to the AKIN and RIFLE criteria; the incidence rate in Chinese studies was higher than that in non-Chinese studies. Regarding risk factors, age (per 1-year: OR = 1.03; per 10-year: OR = 1.40), male (OR = 1.72), BMI (OR = 1.13), history of hypertension (OR = 1.59), preoperative serum creatinine (OR = 1.02), preoperative leukocyte count (OR = 1.04), preoperative lactate (OR = 1.28), renal artery involvement (OR = 3.47), cardiopulmonary bypass time (per 1-minute increase: OR = 1.01), operative time (OR = 1.33), deep hypothermic circulatory arrest time (OR = 1.07), red blood cell transfusion volume (OR = 1.18), and duration of mechanical ventilation (OR = 1.01) may be significantly associated with postoperative AKI following TAAD. Conclusion: The incidence of AKI following TAAD is high, with major risk factors including advanced age, male gender, high BMI, hypertension, elevated preoperative serum creatinine and white blood cell count, renal artery involvement, prolonged cardiopulmonary bypass and deep hypothermic circulatory arrest, increased perioperative blood transfusion, and prolonged mechanical ventilation. Clinically, a comprehensive prevention and control system covering preoperative assessment, intraoperative protection, and postoperative monitoring should be established to reduce the incidence of AKI and improve patient outcomes. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/, PROSPERO CRD420261276938.
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