Evidence map›Paper›PMID 42375874›Full record

ArticleJournal of magnetic resonance open2025

Efficient

Shiraz Nantogma, Shannon L Eriksson, Thomas Theis, Warren S Warren, Boyd M Goodson, Eduard Y Chekmenev

Abstract read
In one paragraph

Article in Journal of magnetic resonance open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shiraz NantogmaDepartment of Chemistry, Integrative Biosciences (IBio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, MI 48202, USA.
Shannon L ErikssonDepartment of Chemistry, School of Medicine, Duke University, Durham, NC 27708, USA.
Thomas TheisDepartment of Chemistry, North Carolina State University, Raleigh, NC 27695-8204, USA.
Warren S WarrenDepartment of Chemistry, Biomedical Engineering, and Radiology, School of Medicine, Department of Physics, Duke University, Durham, NC 27708, USA.
Boyd M GoodsonSchool of Chemical & Biomolecular Sciences and Materials Technology Center, Southern Illinois University, Carbondale, IL 62901, USA.
Eduard Y ChekmenevDepartment of Chemistry, Integrative Biosciences (IBio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, MI 48202, USA.ORCID 0000-0002-8745-8801

Funding

Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI Jennifer L Beebe-Dimmer · 1985 to 2026
$68.4M
Molecular MRI of Brain Metabolism Enabled by Long-Lived Spin StatesR01EB029829 · NIBIB · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI THEIS, THOMAS · 2020 to 2020
$807k
Molecular imaging with a hyperpolarized Vitamin ShotR21EB025313 · NIBIB · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI THEIS, THOMAS · 2018 to 2019
$661k
Rapid low-cost production of contrast agents for metabolic imagingR21EB033872 · NIBIB · WAYNE STATE UNIVERSITY · PI CHEKMENEV, EDUARD · 2023 to 2024
$415k
NCI NIH HHS P30 CA022453NIBIB NIH HHS R01 EB029829NIBIB NIH HHS R21 EB025313NIBIB NIH HHS R21 EB033872
6 · The paper itself

Abstract

Signal Amplification by Reversible Exchange in SHield Enables Alignment Transfer to Heteronuclei (SABRE-SHEATH) is an NMR hyperpolarization technique that relies of the simultaneous exchange of parahydrogen and a to-be-hyperpolarized molecule on the metal center of a polarization-transfer catalyst in a microtesla magnetic field. Until recently, this method has been understood to perform hyperpolarization by establishing level anti-crossings between the nuclear spins of the parahydrogen derived hydrides (acting as a source of hyperpolarization) and those of the substrate. Recently, the application of highly non-intuitive pulse sequences (comprising pulses of microtesla DC fields) was predicted to hyperpolarize nuclear spins more efficiently than the canonical (static-field) SABRE-SHEATH approach. Here we show that by employing a basic "on-off" pulse sequence of rectangular microtesla pulses, it is possible to improve the hyperpolarization efficiency for SABRE-SHEATH of [

Indexed as

HyperpolarizationMetronidazoleNitrogen-15ParahydrogenSabre

Identifiers

PMID42375874
PMCPMC13313728

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.