Evidence map›Paper›PMID 42376016›Full record

ArticleERJ open research2026

Senescence intensifies bleomycin-induced injury in idiopathic pulmonary fibrosis lung epithelial cells.

Jane Read, Andrew T Reid, Claire Thomson, Marshall Plit, Que Tran La, Ross Mejia, Pankaj Saxena, Darryl A Knight, Muriel Lizé, Cecilia M Prêle and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jane ReadSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.
Andrew T ReidHunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Claire ThomsonSchool of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia.
Marshall PlitSaint Vincent's Hospital, Sydney, NSW, Australia.
Que Tran LaSaint Vincent's Hospital, Sydney, NSW, Australia.
Ross MejiaJohn Hunter Hospital, Newcastle, NSW, Australia.
Pankaj SaxenaJohn Hunter Hospital, Newcastle, NSW, Australia.
Darryl A KnightProvidence Health Care Research Institute, Vancouver, BC, Canada.ORCID https://orcid.org/0000-0002-4064-6127
Muriel LizéBoehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany.
Cecilia M PrêleSchool of Medical, Molecular and Forensic Sciences, Murdoch University, Murdoch, WA, Australia.
Christopher L GraingeSchool of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia.
Heiko StahlBoehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany.
Michael SchuligaSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.ORCID https://orcid.org/0000-0001-6742-5028

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease involving injury and a dysregulated repair response of an ageing epithelium. Here we investigate the contribution of senescence and telomere shortening to bleomycin-induced injury in alveolar epithelial cells (EpCs) derived from lung parenchymal tissue of patients with pulmonary fibrosis (PF), predominantly IPF, Methods: Injury responses of EpCs in air-liquid interface (ALI) culture were assessed by ELISA, qPCR and/or immunofluorescence at 48 and 96 h post-bleomycin (30 μg·mL Results: Bleomycin treatment increased markers of inflammation ( Conclusion: This study provides evidence that senescence-associated telomere shortening increases the susceptibility of IPF lung EpCs to injury. Our cell-based lung epithelial injury model has utility as a pre-clinical tool for drug discovery and the evaluation of potential senotherapeutics for IPF treatment.

Identifiers

PMID42376016
PMCPMC13312048

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.