Evidence map›Paper›PMID 42376017›Full record

ArticleERJ open research2026

Exploring glucocorticoid receptor signalling in lymphangioleiomyomatosis.

Alexandra Baiges, Lara Ruiz-Auladell, Irene García, Raúl Rigo-Bonnin, Yan Tang, Elias J Bou-Farhat, Roderic Espín, Rosario T Sanz, Guillermo Pablo Vicent, Mercè Donate-Castillo and 44 more

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Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

54 authors.

Alexandra BaigesProCURE, Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.
Lara Ruiz-AuladellProCURE, Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.
Irene GarcíaProCURE, Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.
Raúl Rigo-BonninDepartment of Biochemistry and Molecular Genetics, Biomedical Diagnostic Center (CDB), Hospital Clinic de Barcelona, Barcelona, Spain.
Yan TangDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Elias J Bou-FarhatDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Roderic EspínProCURE, Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.
Rosario T SanzMolecular Biology Institute of Barcelona, Spanish National Research Council (IBMB-CSIC), Barcelona, Spain.
Guillermo Pablo VicentMolecular Biology Institute of Barcelona, Spanish National Research Council (IBMB-CSIC), Barcelona, Spain.
Mercè Donate-CastilloPrecision Oncology in Girona (OncoGir), Girona Institute for Biomedical Research (IDIBGI), Salt, Spain.
Arzoo ShabbirProCURE, Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.ORCID https://orcid.org/0000-0002-2515-1919
Jonathan Adams-FurmanskiProCURE, Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.
Carmen Herranz-OrsProCURE, Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.
Rosalía LaportaPneumology Service, University Hospital Clínica Puerta del Hierro, Majadahonda, Spain.
Clara SalasDepartment of Pathology, University Hospital Clínica Puerta del Hierro, Majadahonda, Spain.
Piedad UssettiPneumology Service, University Hospital Clínica Puerta del Hierro, Majadahonda, Spain.
Claudia ValenzuelaPneumology Service, La Princesa Research Institute, University Hospital La Princesa, Madrid, Spain.ORCID https://orcid.org/0000-0002-0856-6290
Julio AncocheaPneumology Service, La Princesa Research Institute, University Hospital La Princesa, Madrid, Spain.
José A Rodríguez-PortalMedical-Surgical Unit of Respiratory Diseases, University Hospital Virgen del Rocío, Institute of Biomedicine of Seville (IBiS), Seville, Spain.
María Molina-MolinaNetwork Center for Biomedical Research on Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain.
Álvaro CasanovaPneumology Service, University Hospital of Henares, University Francisco de Vitoria, Coslada, Spain.
Eva Revilla-LópezPneumology Service, Vall d'Hebron University Hospital, Barcelona, Spain.ORCID https://orcid.org/0000-0002-7751-4291
Luis Gómez-CarreraNetwork Center for Biomedical Research on Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain.
Xavier Matias-GuiuArnau de Vilanova University Hospital, Institute for Biomedical Research of Lleida (IRBLleida), University of Lleida, Lleida, Spain.
Miguel Angel PavónCancer Epidemiology Research Program, Catalan Institute of Oncology, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.
Dominik JungInstitute of Pharmacology and Toxicology, Centre for Biomedical Education and Research (ZBAF), School of Medicine, Faculty of Health, Witten/Herdecke University, Witten, Germany.ORCID https://orcid.org/0000-0003-4288-6455
Hagen S BachmannInstitute of Pharmacology and Toxicology, Centre for Biomedical Education and Research (ZBAF), School of Medicine, Faculty of Health, Witten/Herdecke University, Witten, Germany.
Ramón Manuel Lago-LestónLiquid Biopsy Analysis Unit, Translational Medical Oncology (Oncomet), Health Research Institute of Santiago (IDIS), Santiago de Compostela, Spain.
Laura Muinelo-RomayNetwork Center for Biomedical Research on Cancer (CIBERONC), Institute of Health Carlos III, Madrid, Spain.
Xavier FarréGenomes for Life - GCAT Lab Group, CORE Program, Institute Germans Trias i Pujol, Badalona, Spain.
Rafael de CidGenomes for Life - GCAT Lab Group, CORE Program, Institute Germans Trias i Pujol, Badalona, Spain.
Calvin S LeungDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA.
Anthony S ZannasDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Manel EstellerNetwork Center for Biomedical Research on Cancer (CIBERONC), Institute of Health Carlos III, Madrid, Spain.
Jacobo SellaresPneumology Department, Hospital Clinic de Barcelona, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.
Katarzyna BłasińskaDepartment of Lung Diseases III, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland.
Adriana RóżyDepartment of Lung Diseases III, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland.
Paulina SkrońskaDepartment of Lung Diseases III, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland.
Antonio GómezBiosciences Department, Faculty of Sciences and Technology (FCT), University of Vic - Central University of Catalonia (UVic-UCC), Vic, Spain.
Marina K HolzDepartments of Cell Biology and Anatomy, New York Medical College, Valhalla, NY, USA.
Julie S Di MartinoDepartments of Cell Biology and Anatomy, New York Medical College, Valhalla, NY, USA.
David MonkSchool of Biological Sciences, University of East Anglia, Norwich, UK.
Charlotte SeftonDivision of Diabetes, Endocrinology, and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Leanne WalkerDivision of Diabetes, Endocrinology, and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Anne WhiteDivision of Diabetes, Endocrinology, and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Debbie ClementsCentre for Respiratory Research, Translational Medical Sciences, Biodiscovery Institute, National Institute for Health and Care Research, Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK.
Suzanne MillerCentre for Respiratory Research, Translational Medical Sciences, Biodiscovery Institute, National Institute for Health and Care Research, Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK.ORCID https://orcid.org/0000-0001-8508-1871
Simon R JohnsonCentre for Respiratory Research, Translational Medical Sciences, Biodiscovery Institute, National Institute for Health and Care Research, Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK.ORCID https://orcid.org/0000-0002-9837-2763
Hazel J HuntCorcept Therapeutics, Redwood City, CA, USA.
Elizabeth P HenskeDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
David KwiatkowskiDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Elżbieta RadzikowskaDepartment of Lung Diseases III, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland.ORCID https://orcid.org/0000-0002-2585-8594
Francesca MateoProCURE, Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.
Miquel Angel PujanaProCURE, Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Lymphangioleiomyomatosis (LAM) is a rare, low-grade neoplasm that causes progressive cystic lung destruction and is often associated with renal angiomyolipomas (AMLs). Given evidence of pleiotropy linking LAM risk to pulmonary traits, we investigated whether glucocorticoid receptor (GR) signalling might influence LAM biology and clinical features. Methods: We combined cell-based studies, GR inhibition/activation assays, gene expression and single-cell RNA sequencing analyses, and hormone profiling in retrospective and prospective LAM cohorts. Cellular experiments employed murine Results: In LAM/AML models, GR activation by glucocorticoids elicited transcriptional responses, whereas GR inhibition reduced clonogenic potential. GR stimulation was associated with Conclusions: Our findings suggest that GR signalling may contribute to aspects of LAM cell behaviour and disease status. Further investigation of this pathway could clarify its role as a disease modifier and potential therapeutic target.

Identifiers

PMID42376017
PMCPMC13312046

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.