ArticleOpen veterinary journal2026
Efficacy of
Article in Open veterinary journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Background: Inflammation of the dental pulp is commonly associated with intense nociceptive signaling mediated by interleukin-1β (IL-1β), Substance P, and neurokinin-1 receptors (NK1-R). Natural compounds, such as Rosmarinus officinalis, contain bioactive molecules that may alleviate this response, particularly when expressed in nanoemulsions that enhance tissue penetration. Aim: This study explored the modulatory effect of NE-RO on inflammatory and nociceptive markers in an experimental rat model of acute pulpitis. Methods: Thirty healthy male Wistar rats were randomly assigned to six treatment groups, including negative and positive controls, three NE-RO treatment concentrations (0.5, 1.0, and 2.0 mg/ml), and an eugenol comparison group, after 1 week of acclimatization under controlled housing conditions. Pulpitis was induced by lipopolysaccharide application to the exposed pulp chamber. After 24 hours of treatment, the first maxillary molars were processed for immunohistochemical assessment of IL-1β, Substance P, and NK1-R. Data were analyzed using analysis of variance or Kruskal-Wallis tests with a 95% confidence level. Results: Induction of pulpitis significantly elevated IL-1β, Substance P, and NK1-R expression relative to the untreated control. The administration of 2 mg/ml NE-RO resulted in marked reductions in the levels of Substance P (5.0 ± 0.40) and NK1-R (5.5 ± 0.29) compared with the positive control ( Conclusion: Topical application of 2 mg/ml
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