ArticleInternational journal of general medicine2026
Retrospective Analysis of Inflammatory Biomarker Patterns and Platelet Dynamics in Hospitalized Adults.
Article in International journal of general medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Systemic inflammation is common in hospitalized adults and may arise from infectious or non-infectious conditions. Several biomarkers, including WBC, neutrophil count, CRP, PCT, IL-6, and NLR, are widely used in clinical practice but may provide non-equivalent clinical information. Platelets are active participants in inflammatory responses, yet relationships between inflammatory biomarkers and platelet dynamics in hospitalized populations remain incompletely characterized. Methods: This single-center retrospective study included 321 hospitalized adults between December 2024 and December 2025. Baseline biomarkers included WBC, absolute neutrophil count, platelet count, CRP, PCT, IL-6, and dNLR, analyzed according to availability. Spearman correlation assessed biomarker relationships. Infection-related and non-infectious diagnoses, classified using primary clinical diagnoses and available clinical documentation, were compared using the Mann-Whitney Results: WBC and neutrophil count were strongly correlated (r = 0.95, p < 0.0001). CRP was moderately correlated with PCT (r = 0.34, p = 0.002), and PCT was positively correlated with IL-6 (r = 0.55, p < 0.001). Age was not significantly associated with CRP (r = -0.12, p = 0.153) but showed a modest correlation with dNLR (r = 0.165, p = 0.003). CRP, PCT, and IL-6 were higher in infection-related diagnoses than in non-infectious conditions (all p < 0.05). In longitudinal analyses, increases in PCT were associated with decreases in platelet counts (r = -0.45, p < 0.0001), while CRP showed a weaker inverse association with platelet changes (r = -0.21, p = 0.034). Conclusion: Inflammatory biomarkers in hospitalized adults demonstrated heterogeneous correlation patterns consistent with partially distinct inflammatory responses rather than a single uniform inflammatory signal. Leukocyte-based markers and cytokine-associated biomarkers represented partially independent components of systemic inflammation. Dynamic increases in inflammatory activity were associated with platelet decline during hospitalization.
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