Evidence map›Paper›PMID 42376245›Full record

ArticleMaterials today. Bio2026

Self-assembled manganese-based nanoplatforms synergizing immunogenic cell death and STING activation for triple-negative breast cancer.

Min Yang, Ming Qin, Yafeng Liu, Jiaying Li, Yue Yin, Yue Huang, Mengjun Yu, Jing Gong, Shiwen Chen, Jia Wang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Min YangDepartment of Pharmacy, The Second Affiliated Hospital of Third Military Medical University, Chongqing, 400037, China.
Ming QinDepartment of Pharmacy, The Second Affiliated Hospital of Third Military Medical University, Chongqing, 400037, China.
Yafeng LiuDepartment of Pharmacy, The Second Affiliated Hospital of Third Military Medical University, Chongqing, 400037, China.
Jiaying LiDepartment of Pharmacy, The Second Affiliated Hospital of Third Military Medical University, Chongqing, 400037, China.
Yue YinDepartment of Pharmacy, The Second Affiliated Hospital of Third Military Medical University, Chongqing, 400037, China.
Yue HuangDepartment of Pharmacy, The Second Affiliated Hospital of Third Military Medical University, Chongqing, 400037, China.
Mengjun YuDepartment of Pharmacy, The Second Affiliated Hospital of Third Military Medical University, Chongqing, 400037, China.
Jing GongDepartment of Pharmacy, The Second Affiliated Hospital of Third Military Medical University, Chongqing, 400037, China.
Shiwen ChenDepartment of Pharmacy, The Second Affiliated Hospital of Third Military Medical University, Chongqing, 400037, China.
Jia WangDepartment of Pharmacy, The Second Affiliated Hospital of Third Military Medical University, Chongqing, 400037, China.
Qiang ZhouDepartment of Plastic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Xuan ZhangSchool of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kumming, Yunnan, 650500, China.
Guobing LiDepartment of Pharmacy, The Second Affiliated Hospital of Third Military Medical University, Chongqing, 400037, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor immunotherapy has emerged as a promising approach to eliminate cancer by activating host immunity but shows limited efficacy in triple-negative breast cancer (TNBC) due to its low immunogenicity and an immunosuppressive tumor microenvironment (TME). In this study, we developed a manganese-based nanoparticle, termed HLM315, via one-step self-assembly of alendronate-modified hyaluronic acid (HA-AL), the amphiphilic cationic peptide LTX-315, and Mn

Indexed as

cGAS-STING pathwayImmunogenic cell deathOncolytic peptide LTX-315Reactive oxygen speciesSelf-assembled manganese-based nanoparticleTriple-negative breast cancer

Identifiers

PMID42376245
PMCPMC13312589

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.