ArticleBlood red cells & iron2026
Red cell antigen exposures in patients with sickle cell disease receiving transfusion from Black and Hispanic donors.
Article in Blood red cells & iron, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Antibody-Dependent and Antibody-Independent Hemolysis in Sickle Cell Disease.Antibodies (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Patients with sickle cell disease (SCD) have an elevated risk for alloimmunization because of frequent transfusions and antigenic disparities with donors. Extended antigen matching beyond Rhesus (Rh; CcEe) and Kell (K) can reduce alloimmunization but is not broadly applied because of logistic and economic challenges. Red cell antigen exposures may be minimized when donor and patient populations are from similar racial and ethnic backgrounds. This study assessed alloantigen exposure across 35 antigens in patients with SCD who received transfusions from donors who self-identified as Black or Hispanic. Seven hundred units transfused to 28 chronically transfused patients were genotyped using a single nucleotide polymorphism-based assay. When combining Rh and K-matching with donor unit selection from racially similar populations, patients were exposed to an average of 1.6 antigens per transfusion, compared to the previously reported 3.5 exposures per transfusion across the same 35 antigens using a general donor inventory. Among 514 units transfused to Black recipients from Black donors, 22% had no foreign antigen exposure across 35 antigens. The most frequent alloantigen exposures were Jk
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Registered trials
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