ReviewFrontiers in genetics2026
CircRNAs in hepatic lipid metabolism: regulatory mechanisms and clinical implications.
Review in Frontiers in genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Review
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Authors and funding
2 authors.
Funding
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Abstract
Hepatic lipid metabolism homeostasis is crucial for maintaining metabolic health, and its disruption is a central factor in the development of metabolic diseases such as non-alcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated steatotic liver disease (MASLD). Circular RNAs (circRNAs),a novel class of non-coding RNAs characterized by their covalently closed loop structures and remarkable stability, have emerged as key regulators of gene expression. Recent studies have revealed that circRNAs play significant roles in modulating critical hepatic lipid metabolism signaling pathways, including AMPK, mTOR, PPAR, and SREBP. This review systematically summarizes the latest advances in understanding how circRNAs influence these pathways through mechanisms such as acting as molecular sponges for microRNAs, interacting with proteins, and potentially encoding functional peptides. We critically evaluate the experimental models used in key studies, distinguishing between
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.