ArticleFrontiers in cellular and infection microbiology2026
Genetic association between LONG COVID and TMPRSS2 polymorphisms (rs12329760 and rs2070788) in Brazilian healthcare professionals.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long COVID syndrome has a multifactorial cause that is not fully understood and may be influenced by both external and intrinsic factors. In this context, a Genome-Wide Association Study (GWAS) was proposed to evaluate the association between Single Nucleotide Polymorphisms (SNPs) in TMPRSS2 (rs12329760 and rs2070788) and the occurrence of Long COVID in 363 Brazilian healthcare professionals, recruited using a non-probabilistic method. The study employed a self-report questionnaire to collect sociodemographic and clinical data from both the acute and chronic phases and also collected oral mucosa cells for genotypic analysis by qPCR using Taqman probes. The categorized information was analyzed using the PSPP software using Pearson's chi-square test in three genetic statistical models: additive, dominant, and recessive. Assessing long COVID in general, only clinical variables such as increased susceptibility, presence of symptoms, and severity influenced the occurrence of the syndrome. When specifying the main reported symptom, brain fog, females and young adults (18 to 29 years old) are the most vulnerable, and rs2070788 in the recessive model proved to be relevant. This association is more evident when evaluating only the symptomatic group in the post-COVID period, as the additive model also influences the groups. rs12329760 showed no relevant influence on the groups. Therefore, this study provides unprecedented evidence of the association between brain fog and rs2070788, requiring case-control studies to better clarify how this association occurs.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.