ArticleOpen veterinary journal2026
Physiological, molecular, and histological evaluation of the effects of cobalamin on cardiac function in castrated rabbits.
Article in Open veterinary journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Testosterone deficiency is associated with adverse cardiac remodeling, oxidative stress, and inflammation. Aim: To investigate the physiological, biochemical, and histological effects of cobalamin (vitamin B12) supplementation on cardiac physiology in castrated rabbits. Methods: A total of 24 male rabbits were divided into three groups: control (C), castrated (CA), and castrated with cobalamin supplementation (CA + C). Biochemical markers, including cardiac troponin I (cTnI), heart-type fatty acid-binding protein (H-FABP), homocysteine, glutathione (GSH), interleukin-3 (IL-3), galectin-3 (Gal-3), translocator protein (TSPO), and thrombospondin-1 (TSP-1), were measured using Enzyme-Linked Immunosorbent Assay. Myocardial tissue was histologically evaluated alongside Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) and Atrial Natriuretic Peptide (ANP) gene expression analysis using quantitative real-time reverse-transcription PCR. Statistical significance was set at Results: Castration significantly increased the levels of cardiac markers, such as cTnI, H-FABP, homocysteine, IL-3, and Gal-3, while reducing GSH levels ( Conclusion: Cobalamin supplementation mitigates the harmful effects of testosterone deficiency on the heart by improving oxidative stress, inflammation, and cardiac remodeling. These findings support the potential of this drug for correcting cardiovascular dysfunction associated with hormonal deficiencies.
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