Evidence map›Paper›PMID 42376578›Full record

ArticleFrontiers in microbiology2026

Life-death trade-offs: HSV-1 ICP27 differentially modulates intrinsic apoptotic signaling in epithelial and neuron-like cells.

Chiara Nordi, Anna Caproni, Davide Barboni, Davide Proietto, Martina Facchini, Riccardo Fontana, Mattia Buratto, Martina Catani, Peggy Marconi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Cell death network regulation in HSV infection: immune evasion versus host defense.Apoptosis : an international journal on programmed cell death · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chiara NordiLaboratory of Microbiology, Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy.
Anna CaproniLaboratory of Microbiology, Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy.
Davide BarboniLaboratory of Analytical Chemistry, Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.
Davide ProiettoLaboratory of Microbiology, Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy.
Martina FacchiniLaboratory of Microbiology, Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy.
Riccardo FontanaLaboratory of Microbiology, Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.
Mattia BurattoLaboratory of Microbiology, Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy.
Martina CataniLaboratory of Analytical Chemistry, Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.
Peggy MarconiLaboratory of Microbiology, Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herpes simplex virus type 1 (HSV-1) is a well-established model to investigate virus-host interactions due to its ability to modulate cell fate and establish lifelong persistence. Among the immediate-early genes, the multifunctional regulatory protein ICP27, encoded by the

Indexed as

apoptosisHSV-1hTert RPE-1ICP27SH-SY5Y

Identifiers

PMID42376578
PMCPMC13311084

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.