ArticleFrontiers in physiology2026
Impulse oscillometry with quantitative computed tomography provides additional clinical information beyond spirometry in chronic airflow obstruction: a pilot study.
Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Conventional spirometric indices such as forced expiratory volume in 1 second (FEV Methods: Sixty-four subjects with variable pulmonary functions were recruited and stratified into four sub-groups (G1-G4) based on spirometric severity defined by FVC and FEV Results: IOS-based reactances at 10 and 15 Hz (X10 and X15) were significantly more negative in groups with reduced FVC (G2 and 4) than in those with preserved FVC (G1 and 3), whereas resistances did not differ significantly between the sub-groups. The Jacobian and ADI were predominantly decreased in Groups 2 and 4 with FVC<80%. fSAD% was predominantly increased in Groups 3 and 4 with FEV Conclusion: The IOS-based reactances with low frequency were significantly associated with spirometry-pulmonary function and CT-based parenchymal lung function metrics. This finding suggests that a combined approach using IOS and CT can provide a better understanding of parenchymal alterations than spirometry alone.
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