ArticleAnnals of Indian Academy of Neurology2026
A Prospective Study on Autonomic Functions in Idiopathic Inflammatory Myopathies: The AFIIM Study.
Article in Annals of Indian Academy of Neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesDysautonomia in idiopathic inflammatory myopathies (IIM) is an underrecognized and poorly characterized manifestation, despite its potential implications for disease prognosis and clinical management. In this study, we assessed autonomic dysfunction in patients with IIM and investigated its correlation with cardiac imaging biomarkers based on cardiac magnetic resonance imaging (CMRI).
methodsThe study recruited clinically suspected IIM patients aged 10-60 years and age- and sex-matched healthy controls. Evaluations included myositis disease activity assessment tool (MDAAT), autonomic function testing (AFT), tilt table test (TTT), and CMRI with multiparametric mapping.
resultsAmong 31 diagnosed cases of IIM, 28 patients underwent AFT and TTT. Of these, 12 had dermatomyositis, 7 had overlap myositis, 7 had immune-mediated necrotizing myopathy, and 2 had anti-synthetase syndrome. The mean age of onset was 33±12.92 years, with an average illness duration of 16.63±19.43 months, and a female predominance (F:M = 2.1:1). The patients exhibited a lower median total autonomic power (563.2, interquartile range [IQR] = 209.6-1964.6 vs 1606.5, IQR = 1048.6-2676; P = 0.003). The TTT was positive in 10.9% cases. The mean standard deviation of normal-to-normal intervals (SDNN) was lower among the patients (31.7 ± 22.3 vs 43.4 ± 13.7; P = 0.023). SDNN and total autonomic power were negatively correlated with native-T1-mapping (ρ = -0.537, P = 0.009; ρ = -0.638, P = 0.007). An SDNN cut-off of ≤28.68 had a sensitivity of 83.3% and specificity of 76.0% (area under the curve [AUC] = 0.773, P = 0.030), whereas a total power of ≤725.81 had a sensitivity of 83.3% and specificity of 74.0% (AUC = 0.760, P = 0.039) in diagnosing cardiac involvement in IIM.
conclusionsIn this first-of-its-kind study integrating AFT and TTT with CMR to evaluate IIM, patients demonstrated significant autonomic dysfunction, with AFT parameters showing a correlation with CMR findings, thus indicating their potential as a simple predictor of cardiac involvement.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.