Evidence mapPaperPMID 42377641Full record

ReviewCell and tissue banking2026

Hydrogel-based strategies for dentin-pulp complex regeneration: a comprehensive review.

Roya Amani, Mina Rafiee, Erkan Karatas, Seher Hasanzade, Vahid Rahimkhoei, Ali Akbari

Abstract readReview
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In one paragraph

Review in Cell and tissue banking, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Roya AmaniDepartment of Oral Medicine, School of Dentistry, Urmia University of Medical Sciences, Urmia, Iran.
Mina RafieeSolid Tumor Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia, Iran.
Erkan KaratasDepartment of Molecular Biology and Genetics, Erzurum Technical University, 25100, Erzurum, Turkey.
Seher HasanzadeDepartment of Periodontology, Gazi University of Dentistry Faculty, Ankara, Turkey.
Vahid RahimkhoeiSolid Tumor Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia, Iran.
Ali AkbariSolid Tumor Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia, Iran. akbari.a@umsu.ac.ir.ORCID https://orcid.org/0000-0001-6027-292X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical management of dental caries encompasses a spectrum of therapeutic approaches, ranging from conservative restorative procedures to complex endodontic interventions. In cases involving pulp exposure or reversible pulpal injury, vital pulp therapy procedures are considered essential strategies for preserving pulp vitality and maintaining tooth function. This explains the focus of some recent works on developing tissue engineering (TE) approaches, particularly those involving dental stem or progenitor cells, to produce functional dental tissues. Hydrogel-based scaffolds, highly biocompatible three-dimensional (3D) bio/polymeric networks, are particularly attractive because of their ability to mimic the native extracellular matrix and thus serve as suitable scaffolds for tissue engineering, especially for dental pulp regeneration. Their versatility makes them a good candidate for a range of tissue engineering models, and hydrogel-based scaffolds are proving particularly valuable in regenerative medicine. This work reviews both natural and synthetic polymers, focusing on their structures and emerging uses in the regeneration of the dentin-pulp complex.

Indexed as

Dental PulpDentinHydrogelsRegenerationTissue EngineeringAnimalsHumansPolymersStem CellsTissue ScaffoldsHydrogelsPolymersDental pulp regenerationHydrogel-based scaffoldsNatural polymersSynthetic polymersTissue engineering

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.