ReviewAdvanced materials (Deerfield Beach, Fla.)2026
Bioinspired Artificial Bioenergetic Organelles: Design Principles, Nanofabrication and Therapeutic Translation.
Review in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Disruptions in cellular energy metabolism have emerged as central contributors to a broad spectrum of human diseases. While conventional therapeutic strategies can alleviate symptoms, they typically target downstream disease manifestations and often fail to address the underlying energetic dysregulation fueling disease progression. Bioenergetic organelles-engineered from mitochondria and thylakoids-represent a transformative approach by restoring cellular energy homeostasis. Functioning as autonomous metabolic modules, they generate ATP, reductive equivalents, and oxygen in situ, while concurrently modulating redox balance, oxygen tension, and immune-metabolic signaling to restore cellular homeostasis. Recent preclinical evidence highlights their therapeutic versatility, including alleviating tumor hypoxia, restoring bioenergetic function in myocardial and neuronal tissues, reducing inflammatory damage, and normalizing immune cell metabolism. Unlike nanocarriers that primarily serve as delivery vehicles, these bioenergetic organelles actively remodel pathological microenvironments by integrating metabolic restoration with multi-targeted therapeutic actions. This review outlines the design principles, mechanistic basis, and disease-specific applications of artificial bioenergetic organelles, while also addressing key translational challenges such as targeted delivery, immunocompatibility, functional longevity, critical considerations regarding biological safety, and the long-term metabolic fate of these constructs. Positioned at the convergence of bioenergetics, nanotherapeutics, and synthetic biology, these biomimetic systems offer a flexible platform for redefining disease intervention through precise metabolic regulation.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.