ArticleScience progress
Prognostic value of the triglyceride-glucose index combined with glycemic variability for all-cause mortality in patients with sepsis: A retrospective cohort study.
Article in Science progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ObjectiveThis study aimed to evaluate the predictive value of the combined triglyceride-glucose index (TyG) and glycemic variability (GV) for all-cause mortality in critically ill patients with sepsis.MethodsThis retrospective cohort study used MIMIC-IV v3.1 as the development cohort and the temporally independent MIMIC-III CareVue subset as the validation cohort. Patients were divided into six groups based on the median TyG index (9.34) and GV tertiles (≤20.54, 20.54-28.11, and >28.11). The primary outcome was 90-day all-cause mortality. Analyses were performed using Kaplan-Meier survival curves, Cox proportional hazards models, and restricted cubic splines, supplemented with subgroup analyses and external validation.ResultsThis study included 1792 patients from MIMIC-IV and 947 patients from the MIMIC-III CareVue subset. In the fully adjusted Cox proportional hazards model, the G6 group (TyG > 9.34 and GV > 28.11) exhibited the highest 90-day all-cause mortality risk compared with the G1 group (TyG ≤ 9.34 and GV ≤ 20.54) (HR = 2.366, 95% CI: 1.595-3.509). The absolute 90-day mortality rate increased from 10.3% in G1 to 27.2% in G6. Kaplan-Meier analysis revealed significant differences in cumulative mortality across the TyG-GV risk groups during the 90-day follow-up (log-rank P < 0.001), with the lowest survival rate observed in G6. The combined TyG and GV model showed a modest but statistically significant improvement in discrimination compared with the baseline model for 90-day mortality, with the AUC increasing from 0.730 (95% CI, 0.700-0.760) to 0.743 (95% CI, 0.714-0.773) (ΔAUC = 0.013, P = 0.048). The continuous net reclassification improvement (cfNRI) and integrated discrimination improvement (IDI) further supported the incremental value of TyG and GV added to the baseline model. Subgroup analyses showed generally consistent directions of association without significant interactions, and external validation supported the robustness of these findings.ConclusionsThe combined phenotype of elevated TyG index (>9.34) and elevated GV (>28.11) was associated with increased short- and long-term all-cause mortality risks and provided supplementary prognostic information in critically ill patients with sepsis; prospective validation is needed.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.