Balancing Analytical Performance and Sustainability: AGSA and MA Tools-Assessed Fluorimetric Determination of Co-Administered Tadalafil and Omeprazole.

Ebraam B Kamel, Mohamed Badrawy, Israa M Nour

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In one paragraph

Article in Luminescence : the journal of biological and chemical luminescence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Sustainable stability-indicating spectra manipulations for the concurrent quantification of gliclazide and its impurity A as the possible alkaline degradation product: Multi-Color Analytical Profile Assessment.Scientific reports · 2026
Article

4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Ebraam B KamelPharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo, Egypt.ORCID https://orcid.org/0000-0003-0293-9890

Mohamed BadrawyPharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo, Egypt.

Israa M NourPharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A sensitive and environmentally sustainable spectrofluorimetric method was developed for the simultaneous determination of tadalafil (TAD) and omeprazole (OME) in pharmaceutical formulations and spiked human plasma. The method relies on the native fluorescence of TAD measured at λ_ex 280 nm and λ_em 330 nm, while OME was derivatized with 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl) to form a highly fluorescent derivative measured at λ_ex 465 nm and λ_em 535 nm. Experimental variables affecting fluorescence intensity were systematically optimized. The method showed excellent linearity over the concentration ranges of 4-40 ng mL

Indexed as

OmeprazoleTadalafilGreen Chemistry TechnologyHumansSpectrometry, FluorescenceOmeprazoleTadalafilco‐administrationgreen analytical chemistryhuman plasmaomeprazolespectrofluorimetrytadalafil

Identifiers

PMID42378376

DOI10.1002/bio.70547

PMCPMC13349517

What Socratic holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.