Evidence map›Paper›PMID 42379704›Full record

ArticleBMJ open2026

PRIME pilot trial: a protocol for a multicentre pilot randomised controlled trial of PRehabilitation In advance of Major Elective surgery (PRIME).

Joshua J Aube, Dhruvrajsinh Rathod, Danial I McIsaac, Joel L Parlow, Ameer Farooq, Tyler McKechnie, Cagla Ekicioglu, Deborah DuMerton, Brendon J Gurd, Jordan Leitch

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07590141 (PRehabilitation In Advance of Major Elective Surgery), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07590141 nanot yet recruitingnot on this map

PRehabilitation In Advance of Major Elective Surgery: A Pilot Randomized Controlled Trial (PRIME Pilot)

TypeinterventionalSponsorQueen's UniversityRan2026 to 2028Enrolled120ConditionsPrehabilitation, Preoperative Care, Elective Surgical Procedures, Postoperative ComplicationsArmsVirtually Monitored Home-Based Prehabilitation Program
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Joshua J AubeSchool of Kinesiology and Health Studies, Queen's University, Kingston, Ontario, Canada.ORCID http://orcid.org/0009-0006-8353-6127
Dhruvrajsinh RathodSchool of Medicine, Queen's University, Kingston, Ontario, Canada.
Danial I McIsaacAnaesthesiology and Pain Medicine, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.ORCID http://orcid.org/0000-0002-8543-1859
Joel L ParlowDepartment of Anesthesiology and Perioperative Medicine, Queen's University, Kingston, Ontario, Canada.
Ameer FarooqDepartment of General Surgery, Queen's University, Kingston, Ontario, Canada.
Tyler McKechnieDepartment of Surgery, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0002-7668-4096
Cagla EkiciogluDepartment of Surgery, McMaster University, Hamilton, Ontario, Canada.
Deborah DuMertonDepartment of Anesthesiology and Perioperative Medicine, Queen's University, Kingston, Ontario, Canada.
Brendon J GurdSchool of Kinesiology and Health Studies, Queen's University, Kingston, Ontario, Canada.
Jordan LeitchDepartment of Anesthesiology and Perioperative Medicine, Queen's University, Kingston, Ontario, Canada Jordan.Leitch@kingstonhsc.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPrehabilitation is a promising preoperative intervention to improve patient recovery after surgery. Virtually delivered, home-based programmes represent the most efficient model for prehabilitation delivery. However, virtually delivered prehabilitation interventions remain understudied. This manuscript describes the protocol for a pilot randomised controlled trial (RCT) of a virtually monitored, home-based prehabilitation intervention. METHODS AND ANALYSIS: We will conduct a pilot RCT comparing the standard of care to a virtually monitored home-based prehabilitation programme in adults undergoing major elective intrathoracic, intra-abdominal or orthopaedic surgery. Outcome assessors will be blinded to treatment allocation. The intervention consists of 3-4 weeks of a multimodal (exercise, nutrition and psychosocial support) prehabilitation programme supported through a mobile application already in use at the Kingston Health Sciences Centre. The primary feasibility outcomes and their targets are: (1) monthly recruitment rate of >20 participants across all centres and (2) mean intervention adherence of >80%. A sample of 120 participants will be adequate to estimate recruitment and adherence rates with acceptable precision. The secondary outcomes include comparisons of complications, mortality, new-onset disability, length of stay, readmission, quality of life, nutritional status and functional capacity between intervention arms. Secondary outcomes will be collected prior to randomisation, 2 days before surgery and 30 days after surgery. ETHICS AND DISSEMINATION: Ethical approval has been granted by Clinical Trials Ontario (Project ID: 5495). Results will be disseminated through presentations at scientific conferences, peer-reviewed publications and engagement with traditional and social media. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov (NCT07590141).

Indexed as

Elective Surgical ProceduresPreoperative CarePreoperative ExerciseAdultHumansMulticenter Studies as TopicPilot ProjectsPostoperative ComplicationsQuality of LifeRandomized Controlled Trials as TopicAdult surgeryExerciseTelemedicine

Identifiers

PMID42379704
PMCPMC13331144

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.