Evidence map›Paper›PMID 42379758›Full record

ArticleIn vivo (Athens, Greece)

Identification of Differentially Expressed Genes in Non-functioning Pituitary Adenoma by Transcriptome Analysis.

Nisa Devrim Uzkul, Deniz Sunnetci Akkoyunlu, Burak Cabuk, Elif Busra Isik, Elmas Tuna Iskenderoglu, Seda Eren Keskin, Naci Cine, Hakan Savli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nisa Devrim UzkulDepartment of Medical Genetics and Molecular Biology, Health Sciences Institute of Kocaeli University, Kocaeli, Türkiye; nisadevrimuzkul@gmail.com.
Deniz Sunnetci AkkoyunluMedical Genetics Department, Medicine Faculty of Kocaeli University, Kocaeli, Türkiye.
Burak CabukDepartment of Neurosurgery, Pituitary Research Center, Medicine Faculty of Kocaeli University, Kocaeli, Türkiye.
Elif Busra IsikDepartment of Medical Genetics and Molecular Biology, Health Sciences Institute of Kocaeli University, Kocaeli, Türkiye.
Elmas Tuna IskenderogluDepartment of Medical Genetics and Molecular Biology, Health Sciences Institute of Kocaeli University, Kocaeli, Türkiye.
Seda Eren KeskinMedical Genetics Department, Medicine Faculty of Kocaeli University, Kocaeli, Türkiye.
Naci CineMedical Genetics Department, Medicine Faculty of Kocaeli University, Kocaeli, Türkiye.
Hakan SavliMedical Genetics Department, Medicine Faculty of Kocaeli University, Kocaeli, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimNon-functioning pituitary adenoma (NFPA) is the most common pituitary tumor. Due to the lack of hormone hypersecretion, it is often diagnosed when the tumor enlarges and gives compression symptoms. Surgical resection is the primary treatment modality; however, complete remission rates remain suboptimal. In this study, we aimed to investigate differentially expressed genes (DEGs) that may be involved in NFPA pathogenesis. MATERIALS AND

methodsWe used gene expression microarrays to identify DEGs between 45 NFPA samples and 8 normal controls. We performed enrichment analysis to discover signaling pathways associated with NFPA and construct protein-protein interaction (PPI) networks to find out key genes related to the disease.

resultsWe identified 270 up-regulated and 2,428 down-regulated DEGs in NFPA samples compared to normal controls. The cytokine-cytokine receptor interaction was the most significant pathway with notable up-regulation of

conclusion

Indexed as

AdenomaGene Expression ProfilingGene Expression Regulation, NeoplasticPituitary NeoplasmsTranscriptomeBiomarkers, TumorComputational BiologyFemaleGene Regulatory NetworksHumansOligonucleotide Array Sequence AnalysisProtein Interaction MapsSignal TransductionBiomarkers, TumorCCND1cytokine-cytokine receptor interactiondifferential gene expressiongene expression microarrayNon-functioning pituitary adenoma

Identifiers

PMID42379758
PMCPMC13322045

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.