ArticleEnvironmental microbiology2026
A Novel Polyphosphate-Degrading Enzyme Confers Growth on Exogenous Polyphosphate in the Archaeon Haloferax volcanii.
Article in Environmental microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Polyphosphate (polyP) is an inorganic biopolymer of orthophosphate (Pi) that plays roles in many central biochemical processes in microorganisms, including acting as a cellular reservoir of phosphorus. The microbial metabolism of polyP is considered limited to its intracellular cycling by kinases and exopolyphosphatases. However, little is known about polyP metabolism in the Archaea. Notably, many haloarchaea, including Haloferax volcanii, encode homologues of bacterial polyP-synthesising genes, but lack the corresponding genes for its catabolism. Here, we show that H. volcanii possesses a novel polyP-degrading enzyme with characteristics distinguishing it from currently known enzymes. This activity also enabled H. volcanii to grow on exogenous polyP as its sole source of phosphorus. Activity was localised to a discrete protein band by native-PAGE zymography and enzyme assays of cell-free extracts from cells grown on polyP revealed the enzyme was halophilic, required Mn
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.