Evidence map›Paper›PMID 42380053›Full record

ArticleJournal of gastroenterology and hepatology2026

From Chronic Atrophic Gastritis to Low-Grade Intraepithelial Neoplasia: A Proteomic Study on the Sequential Progression of Gastric Precancerous Lesions.

Hui Li, Peiqi Sun, Jiayang Wang, Yitang Wang, Qiwei Zhao, Yuhong Peng, Nuo Xu, Zhidan Zhang, Yuanye Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gastroenterology and hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hui LiDepartment of Gastroenterology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.ORCID https://orcid.org/0009-0000-3605-878X
Peiqi SunDepartment of Gastroenterology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.ORCID https://orcid.org/0009-0008-3614-7238
Jiayang WangDepartment of Gastroenterology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yitang WangDepartment of Gastroenterology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Qiwei ZhaoDepartment of Gastroenterology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yuhong PengDepartment of Gastroenterology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Nuo XuDepartment of Gastroenterology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zhidan ZhangDepartment of Traditional Chinese Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yuanye JiangDepartment of Gastroenterology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Funding

National Natural Science Foundation of China 82474378Shanghai Eastern Talent Plan QNWS2024040Shanghai Putuo District clinical characteristic disease construction project 2023tszb01
6 · The paper itself

Abstract

objectivesThis study aimed to identify differentially expressed proteins (DEPs) in the gastric mucosa of patients with gastric precancerous lesions, establish a differential protein expression profile, and investigate the associated biological processes.

methodsQuantitative proteomic analysis of gastric mucosal tissues from 60 patients-including 20 each diagnosed with chronic atrophic gastritis (CAG), intestinal metaplasia (IM), and low-grade intraepithelial neoplasia (LGIN)-was performed using data-independent acquisition liquid chromatography-tandem mass spectrometry (DIA LC-MS/MS). DEPs were identified using stringent statistical criteria (|log

resultsA total of 591 proteins were identified across the CAG, IM, and LGIN groups. Comparative analysis revealed 21 statistically significantly DEPs primarily associated with metabolic pathways, signal transduction, cytoskeletal organization, viral infection, carcinogenesis, endocytosis, and the spliceosome. Notably, Parkinson's disease protein 7 (PARK7) was consistently downregulated and exhibited differential expression across all three pathological stages.

conclusionThis study delineates characteristic protein alterations in the gastric mucosa throughout the progression of gastric precancerous lesions along the CAG-IM-LGIN sequence. PARK7 demonstrates high diagnostic potential and may serve as a promising biomarker for monitoring disease progression in gastric precancerous conditions.

Indexed as

Carcinoma in SituGastric MucosaGastritis, AtrophicPrecancerous ConditionsProteomicsStomach NeoplasmsAgedChromatography, LiquidChronic DiseaseDisease ProgressionFemaleHumansMaleMiddle AgedProtein Deglycase DJ-1Tandem Mass SpectrometryPARK7 protein, humanProtein Deglycase DJ-1biomarkersgastric precancerous lesionsproteomics

Identifiers

PMID42380053
PMCPMC13432330

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.