Evidence map›Paper›PMID 42380658›Full record

ArticleNature2026

Vaccination elicits HIV broadly neutralizing antibodies in primates.

Jon M Steichen, Patrick J Madden, Claudia T Flynn, Swastik Phulera, Monolina Shil, Oleksandr Kalyuzhniy, Alessia Liguori, Carolyne Kifude, Leigh M Sewall, Christopher A Cottrell and 40 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Finishing the fight against HIV.Nature microbiology · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

50 authors.

Jon M Steichen *Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-4586-3251
Patrick J Madden *Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-4527-5692
Claudia T FlynnIAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.
Swastik PhuleraIAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-1272-7712
Monolina ShilConsortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA, USA.
Oleksandr KalyuzhniyDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-5273-1951
Alessia LiguoriDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Carolyne KifudeIAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.
Leigh M SewallIAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.
Christopher A CottrellDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-3364-3083
Krystal M MaDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Sabyasachi BabooConsortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-4547-5160
Jolene K DiedrichDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Katherine McKenneyIAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.
Allan C deCampVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-1404-4322
Diane G CarnathanEmory National Primate Research Center and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0009-0001-7073-3723
Ivy PhungConsortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-7283-4766
Parham Ramezani-RadConsortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-7276-6660
Ester Marina-ZárateConsortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-1586-404X
Brian FreemanConsortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA, USA.
Zhenfei XieThe Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA.
Jeong Hyun LeeDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Troy SincombDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Nicole PhelpsDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Danny LuDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Diana GoodwinDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Ryan TingleDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-2874-7010
Yumiko AdachiDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Nushin AlaviDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-3848-6280
Jenny TranDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Andy S TranIAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.
Alyne NascimentoEmory National Primate Research Center and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Catherine SovieEmory National Primate Research Center and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Daniel L V BaderDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Hannah VoicIAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.
Xiaoya ZhouIAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0009-0001-5074-5815
Grace PixtonDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Agnes WalshDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Mariane B MeloDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-0409-2454
Torben SchiffnerDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Facundo D BatistaThe Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-1130-9463
Dennis R BurtonDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-6711-9864
Darrell J IrvineDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-8637-1405
James C PaulsonDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-4589-5322
John R YatesConsortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-5267-1672
Gabriel OzorowskiIAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-9695-8138
Andrew B WardIAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-7153-3769
Guido SilvestriEmory National Primate Research Center and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-6602-2470
Shane CrottyConsortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA, USA. shane@lji.org.ORCID http://orcid.org/0000-0002-6484-6262
William R SchiefDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA. schief@scripps.edu.ORCID http://orcid.org/0000-0002-1120-0150

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Glycan dependent epitopes of HIV broadly neutralizing antibodiesR01AI113867 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI PAULSON, JAMES C, SCHIEF, WILLIAM R. · 2014 to 2018
$4.8M
NIAID NIH HHS R01 AI113867NIH HHS P51 OD011132
6 · The paper itself

Abstract

The high antigenic diversity of HIV has been a major obstacle to development of a broadly protective vaccine. Nevertheless, protective HIV broadly neutralizing antibodies (bnAbs) exist and have been proposed as templates for vaccine development

Indexed as

AIDS VaccinesAntibodies, NeutralizingBroadly Neutralizing AntibodiesHIV-1HIV AntibodiesHIV InfectionsAnimalsB-LymphocytesEpitopesFemaleHumansMaleMemory B CellsVaccinationAIDS VaccinesAntibodies, NeutralizingBroadly Neutralizing AntibodiesEpitopesHIV Antibodies

Identifiers

PMID42380658
PMCPMC13489963

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.