Evidence map›Paper›PMID 42380966›Full record

ArticleMicrobiome2026

Population-based characterisation of child and adolescent oral bacterial microbiomes.

Robyn J Wright, Vanessa DeClercq, Christie L Burton, Nicole M Roslin, Alex W Y Chan, Paul D Arnold, Paul Peters, Russell Schachar, Jennifer Crosbie, Morgan G I Langille

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiome, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Robyn J WrightDepartment of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada. robyn.wright@dal.ca.
Vanessa DeClercqDepartment of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.
Christie L BurtonNeurosciences and Mental Health, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada.
Nicole M RoslinNeurosciences and Mental Health, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada.
Alex W Y ChanNeurosciences and Mental Health, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada.
Paul D ArnoldThe Mathison Centre for Mental Health Research & Education, University of Calgary, Calgary, AB, Canada.
Paul PetersHealth Science, Carleton University, Ottawa, ON, Canada.
Russell SchacharNeurosciences and Mental Health, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada.
Jennifer CrosbieNeurosciences and Mental Health, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada.
Morgan G I LangilleDepartment of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe factors influencing the oral microbiome during childhood and adolescence remain under-explored at the population level. Furthermore, details on how the oral microbiome differs with age, varies between individuals of different ethnicities, or is associated with socioeconomic factors and diet in children and adolescents are almost entirely unknown. Saliva samples and detailed demographic, health, diet and socioeconomic data were collected from children and adolescents that attended the Ontario Science Centre (Toronto, Canada) and were enrolled in the Spit for Science cohort. We characterised the bacterial microbiota of 4812 samples using 16S rRNA gene sequencing to make this the largest population cohort of the paediatric oral microbiome to date.

resultsExploration of limited participant genotyping information and more than 50 variables encompassing the demographics, health, diet, socioeconomic status and living environment of participants revealed that almost all of the investigated variables were associated with overall community structure and/or the abundance of specific bacterial genera. However, most of these associations were modest (R

conclusionsThis study provides an atlas of the demographic, health and lifestyle factors that are associated with the salivary bacteriome of children and adolescents. These findings highlight the complex interplay between social, environmental, and biological factors in shaping the developing oral microbiome and underscore the importance of inclusive, demographically diverse cohorts in microbiome research. This presents a reference for the variables that are important to account for in paediatric oral microbiome studies. Video Abstract.

Indexed as

BacteriaMicrobiotaMouthSalivaAdolescentChildChild, PreschoolCohort StudiesDietDNA, BacterialFemaleHumansMaleOntarioRNA, Ribosomal, 16SSequence Analysis, DNADNA, BacterialRNA, Ribosomal, 16SAdolescent microbiomeBacteriomeChild microbiomeCorrelates of the oral microbiomePopulation cohortSaliva microbiome

Identifiers

PMID42380966
PMCPMC13520369

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.