Trial reportBMC oral health2026
A functional Schneiderian membrane-preserving maxillectomy: leveraging mucosal bone-forming potential and clinical effectiveness verification.
Trial report in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07320417 (Schneider Membrane Preservation Combined With In Situ Osteogenesis Strategy), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Schneider Membrane Preservation Combined With In Situ Osteogenesis Strategy: A Feasibility Study of a Modified Maxillary Resection
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectivesThis study aims to propose an improved maxillary resection technique preserving Schneider's membrane and evaluate its clinical value in postoperative bone regeneration, complication control, and functional recovery. MATERIALS AND
methodsThis study included 17 patients who were randomly divided into a modified group (with Schneiderian membrane preserved, n = 8) and a traditional group (n = 9). We compared the two groups on bone regeneration in the maxillary sinus floor after surgery, complication rates (oronasal fistula and empty nose syndrome), and functional recovery.
resultsAfter surgery, clear bone regeneration was seen in all patients in the modified group (bone height 1.89 ± 0.16 mm, volume 614.30 ± 58.73 mm³). The traditional group showed no effective bone regeneration (p < 0.001). None of the patients in the modified group developed oronasal fistula or empty nose syndrome. The modified group also had significantly better outcomes than the traditional group in postoperative bite force (180.63 ± 16.23 N vs. 92.22 ± 29.75 N, p = 1.8 × 10⁻⁶), swallowing function grade(2.75 ± 0.46 vs. 2.11 ± 0.33,p = 0.003) and total UW-QOL score (77.75 ± 5.56 vs. 66.11 ± 6.48,p = 0.001).
conclusionsThis method reduces complication rates and improves functional recovery and quality of life. CLINICAL RELEVANCE: The modified technique leverages the bone-forming potential of the mucosa, enabling immediate closure of the oral-nasal communication and promoting gradual bone regeneration. This approach represents a conceptual shift from simple lesion removal toward functional and structural reconstruction, offering new possibilities for function preservation and structural restoration after maxillary tumor resection. Furthermore, given the small sample size of this study, subsequent validation in larger prospective studies could further facilitate its broader clinical application.
trial registrationTrial was retrospectively registered at clinicaltrials.gov [NCT07320417/2025-12-22].
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.