Evidence map›Paper›PMID 42381713›Full record

ArticleCurrent research in toxicology2026

Subchronic low dose dioxin exposure disrupts hepatic and metabolic homeostasis in a sex- and diet-dependent manner.

Oluwanifemi E Bolatimi, Yuan Hua, Gavin J Phillips, Abigail Ekuban, Paxton Brizendine-Ames, Walter H Watson, Mayukh Banerjee, Frederick A Ekuban, Banrida Wahlang

Abstract read
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In one paragraph

Article in Current research in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Oluwanifemi E BolatimiDepartment of Pharmacology & Toxicology, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
Yuan HuaDepartment of Medicine, Division of Gastroenterology, Hepatology & Nutrition, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
Gavin J PhillipsCollege of Arts and Sciences, University of Louisville, Louisville, KY 40292, USA.
Abigail EkubanDepartment of Medicine, Division of Gastroenterology, Hepatology & Nutrition, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
Paxton Brizendine-AmesDepartment of Pharmacology & Toxicology, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
Walter H WatsonDepartment of Pharmacology & Toxicology, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
Mayukh BanerjeeDepartment of Pharmacology & Toxicology, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
Frederick A EkubanDepartment of Pharmacology & Toxicology, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
Banrida WahlangDepartment of Pharmacology & Toxicology, School of Medicine, University of Louisville, Louisville, KY 40202, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Persistent organic pollutants (POPs) such as "dioxins" have been associated with liver disease development. Population studies have highlighted sex-specific susceptibility to POP-induced liver damage, yet toxicological models looking at sex-specific toxic responses and the combined effects of dioxin mixtures remain insufficiently characterized. This study addresses a critical knowledge gap by investigating sex-dependent effects from exposure to a mixture of dioxin and dioxin-like compounds in the context of sex differences and dietary patterns. Male and female C57BL/6 J mice were fed either a low- (LFD) or high-fat diet (HFD) and administered a weekly dose of 2,3,7,8-tetrachlorodibenzo-

Indexed as

Biological sexDioxinsLiverMetabolicMixture

Identifiers

PMID42381713
PMCPMC13316181

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.