Relationships between anxiety-depression, perceived social support, and in-hospital outcomes among patients with acute myocardial infarction.

Objective: To examine associations between early anxiety-depression symptoms, perceived social support, and in-hospital outcomes in patients with acute myocardial infarction (AMI). Methods: This observational cross-sectional study enrolled 150 consecutive AMI patients. Anxiety-depression symptoms and perceived social support were assessed within 24-72 hours of admission using the Hospital Anxiety and Depression Scale (HADS) and the Perceived Social Support Scale (PSSS). Primary outcome was in-hospital complications; secondary outcomes were length of stay and sleep quality. Multivariable regression models were applied with adjustment for age, cardiac function, emergency PCI, and major comorbidities. Results: Clinically significant anxiety-depression symptoms (HADS ≥11) were present in 44.0% of patients; 27.3% developed at least one complication. Higher HADS scores were independently associated with increased complication risk, prolonged stay, and poorer sleep quality (all P < 0.05). Higher PSSS scores were associated with reduced complication risk, shorter stay, and better sleep quality (all P < 0.05). Psychosocial risk stratification demonstrated a significant gradient across all outcomes (trend P < 0.05), with results consistent across subgroup and sensitivity analyses. Conclusion: Early anxiety-depression symptoms and perceived social support are independently associated with in-hospital outcomes in AMI patients. Routine psychosocial screening may help identify high-risk patients and guide individualized nursing care.