Evidence map›Paper›PMID 42381998›Full record

ReviewJournal of orthopaedic translation2026

Therapeutic effect of mitochondrial transfer on bone tissue diseases: treatment strategy of mitochondrial transplantation and delivery technology.

Zuping Wu, Yuzhe Guan, Ruifeng Song, Peng Chen, Xinyi Fang, Qian Chen, Xiaoyan Chen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of orthopaedic translation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zuping WuStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, 310016, China.
Yuzhe GuanStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, 310016, China.
Ruifeng SongStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, 310016, China.
Peng ChenStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, 310016, China.
Xinyi FangStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, 310016, China.
Qian ChenStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, 310016, China.
Xiaoyan ChenStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, 310016, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disruptions in bone tissue metabolic balance can lead to osteoporosis, osteoarthritis, rheumatoid arthritis, and bone tumors. This disruption typically manifests as reduced or abnormal bone mass, accompanied by pathological changes such as inflammation, fractures, and pain. Recent studies have revealed that mitochondrial dysfunction is prevalent in the aforementioned pathological processes, participating in the regulation of bone tissue cell function and intracellular immune function. Mitochondrial transfer, a newly discovered physiological phenomenon in recent years, can regulate mitochondrial function within recipient cells, thereby influencing metabolic activities, proliferation, differentiation, apoptosis, and immune function of various bone tissue cells. This article primarily reviews the regulatory effects of mitochondrial transfer associated with MSCs on various cells in bone and joint tissues. Given the role of mitochondrial transfer in regulating bone metabolism, we elucidate the application of mitochondrial transfer therapy in the treatment of osteoporosis, osteoarthritis, rheumatoid arthritis, and other bone tissue diseases. The Translational Potential of this Article: This review elaborates in detail on the therapeutic strategies provided by mitochondrial transplantation technology or targeted mitochondrial delivery systems for the treatment of bone tissue diseases, based on the occurrence of mitochondrial transfer in bone tissue tips and its therapeutic effects on related diseases such as OA, RA, osteoporosis.

Indexed as

Extracellular vesicle (EVs)Mitochondrial transferOsteoarthritis (OA)OsteoporosisRheumatoid arthritis (RA)Tunneling nanotubes (TNTs)

Identifiers

PMID42381998
PMCPMC13314807

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.