Evidence map›Paper›PMID 42382173›Full record

ArticleFrontiers in pharmacology2026

Filling the mechanistic and methodological gaps for predicting cytokine release syndrome in humans.

Laure-Alix Clerbaux, Miriam Alb, Birgit Fogal, Thomas Hartung, Virginia K Hench, Hannah Morgan, Felicity N E Gavins, Birgitte Lindeman, Luigi Margiotta-Casaluci, Marek Ostaszewski and 4 more

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Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Laure-Alix ClerbauxInstitute of Experimental and Clinical Research, UCLouvain, Brussels, Belgium.
Miriam AlbUniversitätsklinikum Würzburg, Med. Klinik und Poliklinik II, Lehrstuhl für Zelluläre Immuntherapie, Würzburg, Germany.
Birgit FogalSanofi, Cambridge, MA, United States.
Thomas HartungJohns Hopkins University, Baltimore, MD, United States.
Virginia K HenchOpen BioData Modeling, Raleigh, NC, United States.
Hannah MorganNovartis, Basel, Switzerland.
Felicity N E GavinsCentre for Inflammation Research and Translational Medicine (CIRTM), Department of Biosciences, Brunel University of London, Greater London, United Kingdom.
Birgitte LindemanNorwegian Institute of Public Health, Division of Climate and Environmental Health, Oslo, Norway.
Luigi Margiotta-CasaluciInstitute of Pharmaceutical Science, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.
Marek OstaszewskiLuxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
Kristin ReicheFraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany.
Magdalini SachanaEnvironment Health and Safety Division, Environment Directorate, Organisation for Economic Co-operation and Development (OECD), Paris, France.
Clemens WittwehrEuropean Commission, Joint Research Centre (JRC), Ispra, Italy.
Katherina SewaldFraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytokine release syndrome (CRS) is a severe immune-mediated toxicity frequently associated with immunotherapies such as CAR-T cells and bispecific T-cell engagers. Predicting CRS in humans remains difficult because current animal models and

Indexed as

adverse outcome pathwaycytokine release syndromeimmune-related adverse eventnew approach methodologiesregulatory

Identifiers

PMID42382173
PMCPMC13314603

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.