Evidence map›Paper›PMID 42382394›Full record

ArticleFrontiers in oncology2026

HDAC1-mediated CDK1 decrotonylation inhibits colorectal cancer proliferation by regulating cell cycle and apoptosis.

Dongling Li, Qinrui Cai, Ling Lin, Li Li, Yao Chen, Tianlin Feng, Xiaoya Zhou, Jia Xie, Xiaohong Fu, Chuanwei Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dongling LiCentral laboratory of Chongqing Emergency Medical Center, Chongqing University Central Hospital; School of Medicine, Chongqing University, Chongqing, China.
Qinrui CaiCentral laboratory of Chongqing Emergency Medical Center, Chongqing University Central Hospital; School of Medicine, Chongqing University, Chongqing, China.
Ling LinCentral laboratory of Chongqing Emergency Medical Center, Chongqing University Central Hospital; School of Medicine, Chongqing University, Chongqing, China.
Li LiCentral laboratory of Chongqing Emergency Medical Center, Chongqing University Central Hospital; School of Medicine, Chongqing University, Chongqing, China.
Yao ChenCentral laboratory of Chongqing Emergency Medical Center, Chongqing University Central Hospital; School of Medicine, Chongqing University, Chongqing, China.
Tianlin FengCentral laboratory of Chongqing Emergency Medical Center, Chongqing University Central Hospital; School of Medicine, Chongqing University, Chongqing, China.
Xiaoya ZhouCentral laboratory of Chongqing Emergency Medical Center, Chongqing University Central Hospital; School of Medicine, Chongqing University, Chongqing, China.
Jia XieCentral laboratory of Chongqing Emergency Medical Center, Chongqing University Central Hospital; School of Medicine, Chongqing University, Chongqing, China.
Xiaohong FuCenter Laboratory, The Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing, China.
Chuanwei LiDepartment of Cardiology, Chongqing Medical Emergency Center, Chongqing University Central Hospital, School of Medicine, Chongqing University, Chongqing, China.
Jun XiaoDepartment of Cardiology, Chongqing Medical Emergency Center, Chongqing University Central Hospital, School of Medicine, Chongqing University, Chongqing, China.
Fan YangCentral laboratory of Chongqing Emergency Medical Center, Chongqing University Central Hospital; School of Medicine, Chongqing University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Colorectal cancer (CRC) represents the third most prevalent malignancy globally and ranks as the second leading contributor to cancer-related mortality. Lysine crotonylation, a novel post-translational modification, regulates chromatin dynamics through its dual substrate specificity targeting both histones and non-histone proteins. Methods: We quantitatively compared crotonylation levels between colorectal tumor specimens and paired adjacent normal tissues. The function and mechanism of specific crotonylation sites in hypercrotonylated proteins were further explored both Results: Quantitative analysis revealed a significant elevation of global crotonylation in colorectal tumor specimens compared to adjacent normal tissues. Through LC-MS/MS analysis, we identified the CDK1 9th lysine crotonylated, and that decrotonylated of CDK1-K9 inhibited colorectal tumor proliferation and migration Conclusion: We revealed the role of non-histone protein crotonylation in regulating the proliferation and migration of colorectal tumor. Crotonylation inhibited cell proliferation through the crotonylated CDK1 K9 by arresting the cell cycle and inducing apoptosis, and exerts a synergistic effect with the RO-3306 inhibitor.

Indexed as

Cdk1CRCcrotonylationepigeneticsPTMs

Identifiers

PMID42382394
PMCPMC13314466

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.