ArticleObesity pillars2026
Phenotype tailored lifestyle intervention for weight management in individuals with emotional eating: A secondary analysis of the PHENO-Diet trial.
Article in Obesity pillars, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04073394 ("Mayo Clinic Diet" Individualized Lifestyle Intervention for Obesity Management Based on Obesity Phenotypes), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
"Mayo Clinic Diet" Individualized Lifestyle Intervention for Obesity Management Based on Obesity Phenotypes (PHENO-Diet Trial)
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0 citing papers in PubMed.
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: In a proof-of-concept trial, a phenotype tailored lifestyle intervention (PLI) led to greater weight loss than a standardized lifestyle intervention (SLI). This secondary analysis evaluated the effect of the PLI for individuals with an emotional eating phenotype (EE) on weight loss outcomes, eating behaviors and mood. Methods: This original clinical research article is a secondary analysis of a 12-week, non-randomized, date-of-treatment trial in which adults with obesity underwent phenotyping and were assigned sequentially to either a PLI (N = 84) or a SLI (N = 81). The EE phenotype was defined as a HADS-A (Hospital Anxiety and Depression Scale for Anxiety) score ≥7. Weight loss outcome and changes in eating behaviors and mood were evaluated among participants with EE assigned to an SLI (n = 19) or a PLI (n = 26). Results: Participants with EE assigned to the PLI achieved greater weight loss at 12-weeks compared with those assigned to the SLI (-5.9% ± 4.4 vs. -2.6% ± 4.8; p = 0.02). Participants with EE assigned to the PLI demonstrated reduced HADS-A and HADS-D scores, and the Three-Factor Eating Questionnaire Emotional Eating subscale (TFEQ-EE), while those assigned to the SLI had minimal or no improvements after 12-weeks. Among participants with EE assigned to the PLI, Higher HADS-A scores and lower scores in the Weight Efficacy Lifestyle questionnaire (WEL) negative emotions subscale and TFEQ-EE at baseline were associated with greater weight loss at 12-weeks. (NCT04073394). Conclusion: These findings support tailoring behavioral weight-loss interventions for adults with obesity and EE. Larger randomized studies with longer follow-up are needed to further refine phenotype-based approaches.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.