Evidence map›Paper›PMID 42383006›Full record

ArticleiScience2026

Dysregulation of sphingolipid-metabolizing enzymes in Friedreich's ataxia:

Zenouska Ramchunder, Ester Kalef-Ezra, Saqlain Suleman, Fred Jonathan Edzeamey, Sandor Szunyogh, Owen Gittins, Natalia Castro Mena, Richard Wade-Martins, Adamo Valle, Charareh Pourzand and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zenouska RamchunderDepartment of Biosciences, College of Health, Medicine and Life Sciences (CHMLS), Brunel University of London, London, UK.
Ester Kalef-EzraDepartment of Biosciences, College of Health, Medicine and Life Sciences (CHMLS), Brunel University of London, London, UK.
Saqlain SulemanDepartment of Biosciences, College of Health, Medicine and Life Sciences (CHMLS), Brunel University of London, London, UK.
Fred Jonathan EdzeameyDepartment of Biosciences, College of Health, Medicine and Life Sciences (CHMLS), Brunel University of London, London, UK.
Sandor SzunyoghDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Owen GittinsUniversity of Cambridge, Cambridge, UK.
Natalia Castro MenaDepartment of Biosciences, College of Health, Medicine and Life Sciences (CHMLS), Brunel University of London, London, UK.
Richard Wade-MartinsDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Adamo ValleEnergy Metabolism and Nutrition, Research Institute of Health Sciences (IUNICS), University of the Balearic Islands, Palma, Spain.
Charareh PourzandDepartment of Life Sciences, University of Bath, Bath, UK.
Sara Anjomani VirmouniDepartment of Biosciences, College of Health, Medicine and Life Sciences (CHMLS), Brunel University of London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Friedreich's ataxia (FRDA) is an inherited neurodegenerative disorder caused by a GAA repeat expansion within the

Indexed as

Cell biologyGeneticsMolecular biologyPhysiology

Identifiers

PMID42383006
PMCPMC13316217

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.