ArticleFrontiers in medicine2026
Integrated analysis of the aqueous humor microbiome and lens capsule transcriptome in high myopia cataract: a pilot study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Corrections and comments
- Erratum issued
Authors and funding
8 authors.
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Abstract
Introduction: High myopia is a critical risk factor that accelerates cataract onset and increases surgical complexity, yet the underlying mechanisms remain incompletely understood. Methods: In this study, we collected aqueous humor samples (6 from high myopia cataract patients and 6 from age-related cataract controls) and lens capsule samples (3 per group). 2bRAD-M gene sequencing was used to characterize the aqueous humor microbiome, while RNA-seq was performed to profile transcriptomic changes in the lens capsule. Results: Patients with high myopia cataract exhibited significant alterations in aqueous humor microbial diversity, with decreased abundance of Discussion: These findings suggest that alterations in the aqueous humor microbial community may be associated with the lens metabolic microenvironment and apoptotic pathway activation, thereby linking to cataract progression in high myopia. This study provides a novel perspective on the pathogenesis of high myopia-associated cataract.
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