ArticleJournal of extracellular biology2026
Exosome Secretion Drives Chemo-Resistance of Temozolomide in Glioblastoma.
Wenpei Li, Shaoping Jiang, Kun Liu, Zhi Li, Jun Yang, Weimin Liu, Yuanyu Huang, Minghui Yang, Shuai Guo, Shaobo Ruan
Abstract read
In one paragraphArticle in Journal of extracellular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Wenpei LiSchool of Chemistry and Chemical Engineering School of Life Science School of Interdisciplinary Science Key Laboratory of Molecular Medicine and Biotherapy Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering Beijing Institute of Technology Beijing China.
Shaoping JiangSchool of Chemistry and Chemical Engineering School of Life Science School of Interdisciplinary Science Key Laboratory of Molecular Medicine and Biotherapy Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering Beijing Institute of Technology Beijing China.
Kun LiuSchool of Chemistry and Chemical Engineering School of Life Science School of Interdisciplinary Science Key Laboratory of Molecular Medicine and Biotherapy Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering Beijing Institute of Technology Beijing China.
Zhi LiSchool of Chemistry and Chemical Engineering School of Life Science School of Interdisciplinary Science Key Laboratory of Molecular Medicine and Biotherapy Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering Beijing Institute of Technology Beijing China.
Jun YangSchool of Chemistry and Chemical Engineering School of Life Science School of Interdisciplinary Science Key Laboratory of Molecular Medicine and Biotherapy Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering Beijing Institute of Technology Beijing China.
Weimin LiuSchool of Chemistry and Chemical Engineering School of Life Science School of Interdisciplinary Science Key Laboratory of Molecular Medicine and Biotherapy Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering Beijing Institute of Technology Beijing China.
Yuanyu HuangSchool of Chemistry and Chemical Engineering School of Life Science School of Interdisciplinary Science Key Laboratory of Molecular Medicine and Biotherapy Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering Beijing Institute of Technology Beijing China.
Minghui YangSchool of Chemistry and Chemical Engineering School of Life Science School of Interdisciplinary Science Key Laboratory of Molecular Medicine and Biotherapy Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering Beijing Institute of Technology Beijing China.
Shuai GuoSchool of Chemistry and Chemical Engineering School of Life Science School of Interdisciplinary Science Key Laboratory of Molecular Medicine and Biotherapy Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering Beijing Institute of Technology Beijing China.
Shaobo RuanSchool of Chemistry and Chemical Engineering School of Life Science School of Interdisciplinary Science Key Laboratory of Molecular Medicine and Biotherapy Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering Beijing Institute of Technology Beijing China.ORCID https://orcid.org/0000-0002-6300-4979 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Temozolomide (TMZ) is a first-line chemotherapeutic agent for the treatment of glioblastoma (GBM), while a majority of patients do not effectively respond to TMZ owing to the multiple resistance mechanisms. In this study, we found that TMZ treatment substantially increased the exosome secretion from GBM cell line. The secreted exosomes from TMZ-treated C6 cells maintained typical physicochemical properties, with only slight fluctuation in expression profile of surface markers compared to untreated cell-derived exosomes. Further investigation revealed that increased expression of p53 might be the predominant reason to promote exosome secretion, potentially through the upregulation of six-transmembrane epithelial antigen of prostate 3 (STEAP3) expression under stress condition. Moreover, we identified that pre-treatment with TMZ-induced exosomes could reduce the sensitivity of C6 cells to TMZ and considered that exosome secretion may serve as a potent TMZ resistance mechanism via enhancing anti-apoptotic ability of GBM cells towards TMZ exposure. Proteomics analysis revealed a strategic mechanism to resist TMZ-induced apoptosis by upregulating exosomal proteins associated with biogenesis, chemoresistance, and therapeutic adaption. This finding revealed a considerable TMZ resistance mechanism and provided a new inspiration for preventing exosome biogenesis to resensitise TMZ cytotoxicity towards GBM.
Identifiers
PMID42383157
PMCPMC13317785
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