Evidence map›Paper›PMID 42383180›Full record

ArticleEnvironmental epidemiology (Philadelphia, Pa.)2026

Seasonality and environmental determinants of exhaled nitric oxide in individuals with and without chronic respiratory diseases.

Lorena Torroni, Francesca Locatelli, Pierpaolo Marchetti, Sandra Baldacci, Claudio Gariazzo, Sara Maio, Camillo Silibello, Gianluca Spiteri, Massimo Stafoggia, Giovanni Viegi and 2 more

Abstract read
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In one paragraph

Article in Environmental epidemiology (Philadelphia, Pa.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lorena TorroniUnit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.ORCID https://orcid.org/0000-0002-0707-7153
Francesca LocatelliUnit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
Pierpaolo MarchettiUnit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
Sandra BaldacciInstitute of Clinical Physiology, National Research Council (CNR), Pisa, Italy.
Claudio GariazzoOccupational and Environmental Medicine, Epidemiology and Hygiene Department, Italian Workers' Compensation Authority (INAIL), Roma, Italy.
Sara MaioInstitute of Clinical Physiology, National Research Council (CNR), Pisa, Italy.
Camillo SilibelloARIANET s.r.l., Milano, Italy.
Gianluca SpiteriOccupational Medicine Unit, University Hospital of Verona, Verona, Italy.
Massimo StafoggiaDepartment of Epidemiology, Lazio region Health Service, ASL ROMA1, Roma, Italy.
Giovanni ViegiInstitute of Clinical Physiology, National Research Council (CNR), Pisa, Italy.
Giuseppe VerlatoUnit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.ORCID https://orcid.org/0000-0001-5262-8818
Alessandro MarconUnit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.ORCID https://orcid.org/0000-0002-2778-658X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objective: Fractional exhaled nitric oxide (FeNO) is a biomarker of type-2 lung inflammation. Standardized measurement is essential for accurate diagnosis and monitoring. We assess seasonality and environmental determinants of FeNO in individuals with and without chronic respiratory diseases in the general population. Methods: This is a cross-sectional study on 412 individuals with chronic respiratory diseases (asthma, chronic bronchitis/chronic obstructive pulmonary disease, rhinitis) and 605 individuals without these conditions. Participants, aged 20-65 years, were recruited in the Gene-Environment Interactions in Respiratory Diseases study in Verona, Italy (2008-2014). Geocoded residential addresses were linked to daily PM Results: FeNO levels were higher in subjects with respiratory diseases during the warm season, even after adjusting for pollen exposures; a milder seasonal pattern was observed in subjects without chronic respiratory diseases ( Conclusion: FeNO is a sensitive biomarker of environmental exposures. Overlooking seasonality and environmental factors might impact clinical decision-making in chronic respiratory diseases.

Indexed as

Air pollutionAir temperatureAirway inflammationAsthmaEnvironmental epidemiologyFractional exhaled nitric oxide (FeNO)Rhinitis

Identifiers

PMID42383180
PMCPMC13318099

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.