ArticlemSystems2026
Global distribution of isoprenoid quinones across Bacteria.
Article in mSystems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
8 authors.
Funding
Abstract
Isoprenoid quinones are redox-active lipids essential for numerous cellular processes, including ATP synthesis via electron transport chains. They are found across all domains of life. Their diversity among microbial taxa has established them as chemotaxonomic markers, while recent studies have linked quinone repertoire variations to metabolic adaptations, and have identified novel quinone types. Despite this renewed interest, a comprehensive overview of quinone distribution across Bacteria is missing. Here, we systematically annotated quinone biosynthetic pathways for major quinones (ubiquinone, rhodoquinone, plastoquinone, and menaquinone) across 26,264 high-quality bacterial genomes. We also text-mined quinone data from over 6,000 species in published abstracts to validate our genomic annotations while compiling valuable information on quinone chains. Mapping these data onto a phylogenetic framework provides the most extensive synthesis of quinone distribution in Bacteria to date. Our analysis reveals an unexpectedly dynamic evolutionary history for the two menaquinone-producing pathways. Furthermore, the discovery and experimental validation of a deeply branching ubiquinone pathway in the phylum
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.